Multiple overlapping epitopes in the repetitive unit of the shed acute-phase antigen from Trypanosoma cruzi enhance its immunogenic properties
| Autor: | M. Susana Leguizamón, Carlos A. Buscaglia, Tamara A. Pitcovsky, Paula Alvarez, Oscar Campetella |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Repetitive Sequences
Amino Acid Antigenicity Phage display biology Immunogenicity Trypanosoma cruzi Immunology Neuraminidase Antigens Protozoan biology.organism_classification Microbiology Virology Epitope Bacteriophage Epitopes Infectious Diseases Epitope mapping Antigen parasitic diseases Animals Parasitology Fungal and Parasitic Infections Epitope Mapping Glycoproteins |
| Zdroj: | Infection and immunity. 69(12) |
| ISSN: | 0019-9567 |
| Popis: | The repetitive shed acute-phase antigen (SAPA) from Trypanosoma cruzi was thoroughly mapped by SPOT peptides and phage display strategies, showing that a single SAPA repeat is composed of multiple overlapping B-cell epitopes. We propose that this intricate antigenic structure constitutes an alternative device to repetitiveness in order to improve its immunogenicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|