Innate immune receptors, key actors in cardiovascular diseases
| Autor: | Lisardo Boscá, Carmen Delgado, Rafael I. Jaén, Almudena Val-Blasco, María Fernández-Velasco, Jose Lopez-Sendon, Marta Gil-Fernández, Patricia Prieto, Tarik Smani |
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| Přispěvatelé: | UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
NF-κB nuclear factor κ-light-chain-enhancer of activated B cells innate immune system Nucleotide-binding oligomerization domain-like receptors 030204 cardiovascular system & hematology Pyrin domain STATE-OF-THE-ART REVIEW HF heart failure 0302 clinical medicine cardiovascular disease NOD1 Medicine Receptor Innate immune system Pattern recognition receptor Cardiovascular diseases CARD caspase activation and recruitment domain medicine.symptom Cardiology and Cardiovascular Medicine DAP D-glutamyl-meso-diaminopimelic acid PAMP pathogen-associated molecular pattern nucleotide-binding oligomerization domain-like receptors Medicina Inflammatory response NLR nucleotide-binding oligomerization domain-like receptors I/R ischemia/reperfusion Inflammation Leucine-rich repeat CVD cardiovascular disease ER endoplasmic reticulum 03 medical and health sciences ROS reactive oxygen species NLRP3 NOD Nucleotide-binding oligomerization domain-containing protein DAMPs danger-associated molecular patterns Ca2+ calcium ion TLR toll-like receptor business.industry SR sarcoplasmic reticulum AMI acute myocardial infarction IL interleukin Toll-like receptors 030104 developmental biology toll-like receptors Immunology NLRP nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing receptor business MAPK mitogen-activated protein kinase |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname JACC: Basic to Translational Science Biblos-e Archivo. Repositorio Institucional de la UAM Consejo Superior de Investigaciones Científicas (CSIC) Biblos-e Archivo: Repositorio Institucional de la UAM Universidad Autónoma de Madrid |
| Popis: | Central Illustration Highlights • The present review recapitulates relevant findings related to the role of the receptors of the innate immune system (TLRs and NLRs) in the progression of the most prevalent CVDs. • TLRs and NLRs play a key role in the progression of atherosclerosis, acute myocardial infarction or heart failure. • The development of new specific strategies to impair exacerbated TLR and NLR activation in CVDs are strong candidates for therapy and opens a new research field. Summary Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with increased inflammation that arises mainly from innate immune system activation related to cardiac damage. Sustained activation of the innate immune system frequently results in maladaptive inflammatory responses that promote cardiovascular dysfunction and remodeling. Much research has focused on determining whether some mediators of the innate immune system are potential targets for CVD therapy. The innate immune system has specific receptors—termed pattern recognition receptors (PRRs)—that not only recognize pathogen-associated molecular patterns, but also sense danger-associated molecular signals. Activation of PRRs triggers the inflammatory response in different physiological systems, including the cardiovascular system. The classic PRRs, toll-like receptors (TLRs), and the more recently discovered nucleotide-binding oligomerization domain-like receptors (NLRs), have been recently proposed as key partners in the progression of several CVDs (e.g., atherosclerosis and heart failure). The present review discusses the key findings related to the involvement of TLRs and NLRs in the progression of several vascular and cardiac diseases, with a focus on whether some NLR subtypes (nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain-containing receptor 3 and nucleotide-binding oligomerization domain-containing protein 1) can be candidates for the development of new therapeutic strategies for several CVDs. |
| Databáze: | OpenAIRE |
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