Bicêtre hospital experience with sirolimus-based therapy in human renal transplantation: the sirolimus European renal transplant study

Autor:	Lars Bäckman, C Brattström, Henri Kreis, Dominique Durand, J.-L Touraine, José M. Morales, J. M. Campistol, L. Wramner, K Claesson, R. Y. Calne, Carl-Gustav Groth, Bernard Charpentier, Philippe Lang
Rok vydání:	2003
Předmět:	Graft Rejection medicine.medical_specialty Prednisolone Urinary system Hypercholesterolemia Azathioprine Methylprednisolone Gastroenterology Hospitals University chemistry.chemical_compound Adrenal Cortex Hormones Internal medicine medicine Humans Hypertriglyceridemia Sirolimus Transplantation Creatinine Leukopenia business.industry equipment and supplies Kidney Transplantation Hypokalemia Surgery surgical procedures operative chemistry Cyclosporine Prednisone Trough level Drug Therapy Combination France medicine.symptom business Immunosuppressive Agents medicine.drug
Zdroj:	Transplantation Proceedings. 35:S58-S61
ISSN:	0041-1345
Popis:	In 11 European centers, first cadaveric renal allograft recipients were randomized to CsA (n = 42) or sirolimus (n = 41). Dosing of these agents was concentration-controlled and open-labeled. All patients received corticosteroids and azathioprine. At 12 months, graft survival (98% sirolimus vs 93% CsA), patient survival (100% vs 98%), and incidence of biopsy-confirmed acute rejection (41% vs 38%) were similar. Serum creatinine was lower with sirolimus, significantly (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1bde854dcb67c5edcadc303deb7622 https://doi.org/10.1016/s0041-1345(03)00213-6 Zobrazit plný text záznamu Full Text from ScienceDirect