Serum levels of soluble CD44 variant isoforms are elevated in rheumatoid arthritis
| Autor: | I. Rech-Weichselbraun, R. Ruckser, E. M. Kittl, W. Hinterberger, G. Haberhauer, K. Bauer, S. Selleny |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Gene isoform medicine.medical_specialty Immunology Enzyme-Linked Immunosorbent Assay Blood Sedimentation Arthritis Rheumatoid Hemoglobins Exon Rheumatology Rheumatoid Factor Internal medicine Immunopathology medicine Humans Immunology and Allergy Aged Aged 80 and over Autoimmune disease biology business.industry CD44 Middle Aged medicine.disease Blood Cell Count C-Reactive Protein Hyaluronan Receptors Treatment Outcome Endocrinology Immunoglobulin M Antibodies Antinuclear Rheumatoid arthritis Soluble cd44 biology.protein Female business Immunosuppressive Agents |
| Zdroj: | Rheumatology International. 16:181-186 |
| ISSN: | 1437-160X 0172-8172 |
| Popis: | Serum levels of soluble CD44 variant proteins including sequences encoded by exon v5 and exon v6 (sCD44v5, sCD44v6) were determined in patients with inflammatory rheumatic diseases: 56 with rheumatoid arthritis (RA+) and 31 with miscellaneous inflammatory rheumatic diseases (MIRD). There were very significantly higher serum levels of sCD44v5 and sCD44v6 in patients with RA+ than in those with MIRD (RA+ to MIRD: sCD44v5: 81 +/- 54 ng/ml to 33 +/- 13 ng/ml; sCD44v6: 237 +/- 124 ng/ml to 166 +/- 53 ng/ml; both P0.001). In RA+ elevated serum levels of sCD44v5 were correlated with the inflammatory activity of disease. In 17 patients with RA+ three or four follow-up measurements of sCD44v5 were performed within 6 months. The development of sCD44v5 serum levels reflected the clinical course of disease in the patients investigated. |
| Databáze: | OpenAIRE |
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