Complexation of thiomalic acid with mercury(II) and lead(II) under physiological conditions
| Autor: | Yoshiaki Kinjo, Masunobu Maeda, Kaname Ito, Kazuhiro Wakabayashi, Kohji Honda, Kohji Okada |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
chemistry.chemical_classification
Carbon Isotopes Thiomalates Binding Sites Magnetic Resonance Spectroscopy Metal ions in aqueous solution Potentiometric titration Inorganic chemistry Mercury Nuclear magnetic resonance spectroscopy Biochemistry Medicinal chemistry Inorganic Chemistry Kinetics chemistry.chemical_compound Dicarboxylic acid Lead chemistry Potentiometry Chelation Carboxylate Thiomalic acid Chemical equilibrium Chelating Agents |
| Zdroj: | Journal of Inorganic Biochemistry. 42:37-45 |
| ISSN: | 0162-0134 |
| DOI: | 10.1016/0162-0134(91)80030-l |
| Popis: | The complex formation of thiomalic acid (H3L) with Hg(II) and Pb(II) was investigated under physiological conditions of 37 degrees C and 0.15 mol dm-3 NaCl by potentiometric titrations using glass electrodes. From the analysis of the emf data in the two systems by use of computer program MIQUV it was concluded that the species formed in the two systems are [HgH4L2], [HgH3L]-, [HgH2L2]2-, [HgHL2]3-, [HgHL], [HgL]-, [HgL2]4-, [Hg(OH)L]2-, [Hg(OH)L2]5-, [PbH2L2]2-, [PbH2L]+, [PbHL2]3-, [PbHL], [PbL]-, [Pb(OH)L]2-, and [Pb(OH)2L]3-. The hydrolytic reactions of Hg(II), data on which were used in the analysis of the above system, were also studied by separate potentiometric titrations. Measurements of 13C NMR spectra of [HgL2]4- and [PbL]- and [PbHL2]3- in D2O solutions suggested that the ligand coordinates with both the metal ions through the sulfhydryl group and one of the two carboxylate groups in such a way that the five-membered chelate ring is formed within the complexes. |
| Databáze: | OpenAIRE |
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