Non-genomic signaling of steroid receptors in cancer
| Autor: | Virginie Vlaeminck-Guillem, Muriel Le Romancer, Olivier Tredan, Coralie Poulard, Charlène Thiebaut |
|---|---|
| Přispěvatelé: | Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Centre Léon Bérard [Lyon], Manship, Brigitte |
| Rok vydání: | 2021 |
| Předmět: |
Male
Receptors Steroid Non-genomic signaling Estrogen receptor Breast Neoplasms [SDV.CAN]Life Sciences [q-bio]/Cancer Glucocorticoid receptor Biology Biochemistry Progesterone receptor Prostate cancer Endocrinology Breast cancer [SDV.CAN] Life Sciences [q-bio]/Cancer medicine Transcriptional regulation Humans Molecular Biology Transcription factor Prostatic Neoplasms Cancer medicine.disease Gene Expression Regulation Neoplastic Androgen receptor Receptors Estrogen ERα36 Nuclear receptor Receptors Androgen Cancer research Female Receptors Progesterone Signal Transduction |
| Zdroj: | Molecular and Cellular Endocrinology Molecular and Cellular Endocrinology, 2021, 538, pp.111453. ⟨10.1016/j.mce.2021.111453⟩ |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2021.111453 |
| Popis: | International audience; Steroid receptors (SRs) are members of the nuclear receptor family, which are ligand-activated transcription factors. SRs regulate many physiological functions including development and reproduction, though they can also be involved in several pathologies, especially cancer. Highly controlled cellular responses to steroids involve transcriptional regulation (genomic activity) combined with direct activation of signaling cascades (non-genomic activity). Non-genomic signaling has been extensively studied in cancer, mainly in breast cancer for ER and PR, and prostate cancer for AR. Even though most of the studies have been conducted in cells, some of them have been confirmed in vivo, highlighting the relevance of this pathway in cancer. This review provides an overview of the current and emerging knowledge on non-genomic signaling with a focus on breast and prostate cancers and its clinical relevance. A thorough understanding of ER, PR, AR and GR non-genomic pathways may open new perspectives for the development of therapeutic strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect