Quercetin nanocomposite as novel anticancer therapeutic: improved efficiency and reduced toxicity
| Autor: | Francesca Iemma, Giuseppe Cirillo, Marco Cecchini, Orazio Vittorio, Silke Hampel, Francesco Puoci, Nevio Picci, Paolo Domenico Parchi |
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| Rok vydání: | 2013 |
| Předmět: |
Antioxidant
DPPH Cell Survival medicine.medical_treatment Flavonoid Radical polymerization Carbon nanotubes Pharmaceutical Science Antineoplastic Agents Apoptosis Free radical grafting Anticancer activity Antioxidants Nanocomposites chemistry.chemical_compound medicine Organic chemistry Humans heterocyclic compounds Viability assay chemistry.chemical_classification ABTS Nanocomposite Nanotubes Carbon chemistry Quercetin Polymer therapeutics Nuclear chemistry HeLa Cells |
| Zdroj: | European journal of pharmaceutical sciences 49 (2013): 359–365. doi:10.1016/j.ejps.2013.04.008 info:cnr-pdr/source/autori:Cirillo, Giuseppe; Vittorio, Orazio; Hampel, Silke; Iemma, Francesca; Parchi, Paolo; Cecchini, Marco; Puoci, Francesco; Picci, Nevio/titolo:Quercetin nanocomposite as novel anticancer therapeutic: Improved efficiency and reduced toxicity/doi:10.1016%2Fj.ejps.2013.04.008/rivista:European journal of pharmaceutical sciences/anno:2013/pagina_da:359/pagina_a:365/intervallo_pagine:359–365/volume:49 |
| ISSN: | 1879-0720 |
| Popis: | A three-functional nanocomposite was prepared by radical polymerization of methacrylic acid around carbon nanotubes in the presence of Quercetin as biologically active molecule and proposed as new anticancer therapeutic. The so-obtained hybrid material was characterized by FT-IR, Raman, SEM, TEM analyses, while the functionalization degree of 2.33 mg of Quercetin per g of composite was assessed by Folin-Ciocalteu test. Antioxidant test (DPPH and ABTS) showed that the covalent coupling did not interfere with the antioxidant properties of the flavonoid, while the anticancer activity was greatly enhanced with a recorded IC50 value much lower than free Quercetin. Cell viability tests on healthy cells demonstrated no-toxicity of the conjugate (c) 2013 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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