Cholecystokinin octapeptide (CCK-8), ceruletide and analogues of ceruletide: Effects on tremors induced by oxotremorine, harmine and ibogaine a comparison with prolyl-leucylglycine amide (MIF), anti-parkinsonian drugs and clonazepam
| Autor: | G. Zetler |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Trihexyphenidyl Mice Inbred Strains Pharmacology Clonazepam Sincalide Antiparkinson Agents Mice Structure-Activity Relationship Cellular and Molecular Neuroscience chemistry.chemical_compound Alkaloids Harmine Internal medicine Tremor medicine Oxotremorine Haloperidol Animals Hypnotics and Sedatives Ceruletide Benzodiazepinones Chemistry Ibogaine Peptide Fragments Biperiden Endocrinology Cholecystokinin Drug Antagonism Oligopeptides medicine.drug |
| Zdroj: | Neuropharmacology. 22:757-766 |
| ISSN: | 0028-3908 |
| Popis: | Cholecystokinin octapeptide (CCK-8), ceruletide (caerulein, CER) and 10 analogues of ceruletide, were studied in mice for antagonism of the tremors induced by harmine (5 mg/kg, s.c.), ibogaine (20 mg/kg, s.c.) and oxotremorine (0.2 mg/kg, s.c.). The following reference drugs were tested for comparison: prolyl-leucylglycine amide (MIF), atropine, haloperidol, biperiden, ethopropazine, trihexyphenidyl, methixene and clonazepam. All treatments were subcutaneous, the antagonists being given 10 min (in some trials 30 min) before the tremorogen. Tremorolytic potency (ED50) was calculated from dose-response curves. Against the tremors induced by either harmine or ibogaine, CCK-8 and ceruletide, as well as many of the analogues of ceruletide had greater tremorolytic potency than the reference drugs. Against oxotremorine, however, ceruletide and its most potent analogue, Nle8-CER (other analogues were not tested) were inactive and MIF showed very little effectiveness. Additional experiments on hypothermia and sedation as well as evaluation of previous studies on other central actions suggested that the tremorolytic effect of CCK-like peptides is independent of other central effects. The CCK-like peptides may play a physiological role in the regulation of extrapyramidal motor activity. |
| Databáze: | OpenAIRE |
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