Frequency-dependent changes in amplitude of low-frequency oscillations in depression: A resting-state fMRI study
Autor: | Yawei Zeng, Mingrui Xia, Gang Wang, Xin Yu, Wenji Dai, Ke Li, Qinge Zhang, Zhen Jin, Tian-Mei Si, Yun-Ai Su, Li Wang, Qingmei Kong |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male Periodicity medicine.medical_specialty Adolescent Precuneus Ventromedial prefrontal cortex Inferior frontal gyrus Audiology Brain mapping Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Brain Mapping Depressive Disorder Major Resting state fMRI General Neuroscience Precentral gyrus Middle Aged Magnetic Resonance Imaging 030227 psychiatry medicine.anatomical_structure Posterior cingulate Female Low-frequency oscillation Psychology Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Neuroscience Letters. 614:105-111 |
ISSN: | 0304-3940 |
Popis: | Objective We conducted this fMRI study to examine whether the alterations in amplitudes of low-frequency oscillation (LFO) of major depressive disorder (MDD) patients were frequency dependent. Materials and methods The LFO amplitudes (as indexed by amplitude of low-frequency fluctuation [ALFF] and fractional ALFF [fALFF]) within 4 narrowly-defined frequency bands (slow-5: 0.01–0.027 Hz, slow-4: 0.027–0.073 Hz, slow-3: 0.073–0.198 Hz, and slow-2: 0.198–0.25 Hz) were computed using resting-state fMRI data of 35 MDD patients and 32 healthy subjects. Repeated-measures analysis of variance (ANOVA) was performed on ALFF and fALFF both within the low frequency bands of slow-4 and slow-5 and within all of the four bands. Results We observed significant main effects of group and frequency on ALFF and fALFF in widely distributed brain regions. Importantly, significant group and frequency interaction effects were observed in the ventromedial prefrontal cortex, inferior frontal gyrus, precentral gyrus, in a left-sided fashion, the bilateral posterior cingulate and precuneus, during ANOVA both within slow-4 and slow-5 bands and within all the frequency bands. Conclusions The results suggest that the alterations of LFO amplitudes in specific brain regions in MDD patients could be more sensitively detected in the slow-5 rather than the slow-4 bands. The findings may provide guidance for the frequency choice of future resting-state fMRI studies of MDD. |
Databáze: | OpenAIRE |
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