Phrenic nerve function in patients with diaphragmatic weakness and systemic lupus erythematosus
| Autor: | Richard L. Pardy, Peter D. Paré, Pearce G. Wilcox, Howard B. Stein, Stephen D. Clarke |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Weakness Diaphragm Action Potentials Critical Care and Intensive Care Medicine Muscular Diseases Medicine Humans Lupus Erythematosus Systemic Diaphragmatic weakness Myopathy Phrenic nerve Lupus erythematosus business.industry Respiratory disease medicine.disease Surgery Diaphragm (structural system) Electrophysiology Phrenic Nerve Respiratory failure Anesthesia Female medicine.symptom Cardiology and Cardiovascular Medicine business Lung Volume Measurements Pulmonary Ventilation |
| Zdroj: | Chest. 93(2) |
| ISSN: | 0012-3692 |
| Popis: | Diaphragmatic weakness has been identified as one of the pulmonary manifestations of systemic lupus erythematosus. Whether this weakness results from a neuropathic or myopathic process has not been established. Thirty patients with SLE were screened for the presence of inspiratory muscle (IM) weakness. Detailed studies were performed in nine with IM weakness. All nine were found to have diaphragmatic weakness (mean +/- SD, maximal transdiaphragmatic pressure 50 +/- 12 cmH2O). Phrenic nerve latencies, evaluated using transcutaneous stimulation, were normal in all individuals excluding a demyelinating neuropathy. Compound diaphragm action potential (CDAP) with phrenic nerve stimulation was normal in six of these nine patients. Reduced CDAP in three of nine patients was consistent either with axonal degeneration of the phrenic nerve or diaphragm myopathy. Nerve conduction and electromyographic studies on peripheral nerves and muscles respectively failed to demonstrate an associated generalized neuropathy or myopathy. We conclude that diaphragmatic weakness in patients with SLE is both common and is very unlikely to be caused by a phrenic neuropathy. |
| Databáze: | OpenAIRE |
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