Cystic neoplasms of the pancreas. A clinicopathologic study, including DNA flow cytometry
| Autor: | Mark S. Talamonti, David L. Nahrwold, Steven F. Sener, Eric Y. T. Yang, David R. Brenin, George K. Haines, Raymond J. Joehl |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease medicine.medical_treatment Cystadenocarcinoma S Phase Pancreatectomy Postoperative Complications Actuarial Analysis Predictive Value of Tests Cystadenoma Mucinous medicine Humans Neoplasm Invasiveness Survival analysis Mucinous cystadenoma Aged Retrospective Studies Aged 80 and over business.industry Cystadenoma Serous Retrospective cohort study DNA Neoplasm Middle Aged medicine.disease Flow Cytometry Survival Analysis Surgery Pancreatic Neoplasms medicine.anatomical_structure Predictive value of tests Lymphatic Metastasis Cystadenoma Female Neoplasm Recurrence Local business Pancreas Follow-Up Studies |
| Zdroj: | Archives of surgery (Chicago, Ill. : 1960). 130(10) |
| ISSN: | 0004-0010 |
| Popis: | Objective: To review the classification, clinical behavior, and appropriate therapy for cystic neoplasms of the pancreas. We examined patient demographics, clinical parameters, preoperative imaging modalities, histologic findings, and tumor DNA content to determine which best predict outcome. Design: Case series and survey of pathologic specimens. Setting: Tertiary care center. Patients: Twenty-two patients with cystic neoplasms of the pancreas treated at affiliates of Northwestern University Medical School, Chicago, Ill. Main Outcome Measures: Predictive value of preoperative testing, tumor DNA content, patient survival. Results: In 20 patients undergoing computed tomographic scan, the tumor was visualized in every case. All other imaging studies evaluated were less likely to demonstrate the lesion. Eight of 10 patients with serous cystadenomas were alive with no evidence of disease at the time of this report; one patient was alive with local recurrence, and a second patient had died of unrelated causes. All patients with mucinous cystadenomas were alive with no evidence of disease. Three of seven patients with cystadenocarcinomas had aneuploid, high S-phase tumors, and one had a diploid, high S-phase tumor; all four died (mean survival, 4.8 months). Two patients with cystadenocarcinomas had diploid, low S-phase tumors; both were long-term survivors but died of their disease at 8.6 and 9.3 years. Conclusions: (1) Computed tomographic scan is the most valuable diagnostic imaging study for preoperative evaluation of these patients. (2) Precise preoperative determination of tumor type is not possible. (3) DNA flow cytometry may help identify patients with aggressive tumors who may benefit from adjuvant chemoradiation. (Arch Surg. 1995;130:1048-1054) |
| Databáze: | OpenAIRE |
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