Fatal myocardial aspergillosis in an immunosuppressed child

Autor: Yves D. Pastore, Marie-Anne Brundler, Alain Gervaix, Sylviane Hanquinet, Bernard Chapuis, Hulya Ozsahin, Claudine Helg, James Ronald Humbert, Raymond Miralbell, Pierre Wacker, Michel Starobinski
Rok vydání: 2002
Předmět:
Pathology
medicine.medical_specialty
Antifungal Agents
Heart disease
Opportunistic infection
Aspergillosis/diagnosis/drug therapy/microbiology
medicine.medical_treatment
Amphotericin B/therapeutic use
Lung Diseases
Fungal/drug therapy/microbiology
Autopsy
Aspergillosis
ddc:616.0757
Leukemia
Myeloid
Acute/complications/drug therapy
Immunocompromised Host
Fatal Outcome
Aspergillus/isolation & purification
Myocarditis/diagnosis/drug therapy/microbiology
Internal medicine
Amphotericin B
medicine
Humans
Pericarditis
Pericarditis/diagnosis/drug therapy/microbiology
Child
Mycosis
Pneumonitis
ddc:618
Lung Diseases
Fungal
business.industry
Hematopoietic Stem Cell Transplantation
Immunosuppression
medicine.disease
Transplantation
Leukemia
Myeloid
Acute
Myocarditis
Aspergillus
Antifungal Agents/therapeutic use
Female
business
Zdroj: Journal of Pediatric Hematology / Oncology, Vol. 23, No 7 (2001) pp. 456-9
ISSN: 1077-4114
Popis: A girl with resistant acute myeloid leukemia (AML) had a stem cell transplantation. Preceding transplantation, she had recurrent pneumonitis. No causative agent was identified. Despite several antibiotics including high-dose liposomal amphotericin-B, pulmonary infection progressed. Aspergillosis, always considered, could not be documented. She died from cardiac arrest on the second day after transplantation, with no forewarning of previous heart disease. Pericardial and myocardial aspergillosis was an autopsy finding. Pericardial and myocardial aspergillosis, rare manifestations of systemic aspergillosis, should be considered in any immunocompromised patient with long-lasting pulmonary infection, even in the absence of specific cardiac findings.
Databáze: OpenAIRE
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