A diffusion tensor imaging and neurocognitive study of HIV-positive children who are HAART-naïve 'slow progressors'
| Autor: | Leigh Schrieff, Nicole Philipps, Jacqueline Hoare, Charity Oduro, Dan J. Stein, Kevin G. F. Thomas, Christine Mulligan, Jean-Paul Fouche, Bruce S Spottiswoode, Kirsty Donald, Victoria Webster, Heather J. Zar, Robert H. Paul, Heidre Bezuidenhout |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Perforant Pathway HIV Infections Audiology Neuropsychological Tests Corpus callosum Corpus Callosum Cellular and Molecular Neuroscience South Africa Cognition Visual memory Internal Capsule Virology Antiretroviral Therapy Highly Active Fractional anisotropy Task Performance and Analysis medicine Humans Longitudinal Studies Psychiatry Child Superior longitudinal fasciculus Neuropsychology Wechsler Scales Wechsler Adult Intelligence Scale medicine.anatomical_structure Diffusion Tensor Imaging Neurology Case-Control Studies Disease Progression Female Neurology (clinical) Psychology Neurocognitive Diffusion MRI |
| Zdroj: | Journal of neurovirology. 18(3) |
| ISSN: | 1538-2443 |
| Popis: | There are few neuropsychological or neuroimaging studies of HIV-positive children with “slow progression”. “Slow progressors” are typically defined as children or adolescents who were vertically infected with HIV, but who received no or minimal antiretroviral therapy. We compared 12 asymptomatic HIV-positive children (8 to 12 years) with matched controls on a neuropsychological battery as well as diffusion tensor imaging in a masked region of interest analysis focusing on the corpus callosum, internal capsule and superior longitudinal fasciculus. The “slow progressor” group performed significantly worse than controls on the Wechsler Abbreviated Scale of Intelligence Verbal and Performance IQ scales, and on standardised tests of visuospatial processing, visual memory and executive functioning. “Slow progressors” had lower fractional anisotropy (FA), higher mean diffusivity (MD) and radial diffusivity (RD) in the corpus callosum (p = |
| Databáze: | OpenAIRE |
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