Contribution of cortical lesion subtypes at 7T MRI to physical and cognitive performance in MS
| Autor: | Thomas Benner, Nancy Madigan, A. Scott Nielsen, Revere P. Kinkel, Emanuele Tinelli, Caterina Mainero |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Multiple Sclerosis Brain damage Neuropsychological Tests Article White matter Disability Evaluation medicine Humans Effects of sleep deprivation on cognitive performance Clinically isolated syndrome Expanded Disability Status Scale medicine.diagnostic_test Multiple sclerosis Brain Magnetic resonance imaging Cognition medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Cross-Sectional Studies Female Neurology (clinical) Radiology medicine.symptom Psychology Cognition Disorders |
| Popis: | Evaluate cross-sectionally the contribution of focal cortical lesion (CL) subtypes at ultra-high-field MRI and traditional MRI metrics of brain damage to neurologic disability and cognitive performance in a heterogeneous multiple sclerosis (MS) cohort.Thirty-four patients with early or established disease including clinically isolated syndrome, relapsing-remitting MS, and secondary progressive MS were scanned on a human 7-tesla (7T) (Siemens) scanner to acquire fast low-angle shot (FLASH) T2*-weighted images for characterization of white matter and deep gray matter lesion volume, and CL types. Patients also underwent anatomical 3T MRI for cortical thickness estimation, and neuropsychological testing within 1 week of the 7T scan. Twenty-seven patient scans were acceptable for further analysis. Neurologic disability was measured using the Expanded Disability Status Scale.Type III-IV CLs had the strongest relationship to physical disability (ρ = 0.670, p0.0001). White matter lesion volume and type I CLs are each significantly associated with 6 of 11 neuropsychological test variables. Type III-IV CLs significantly correlate with 4 of 11 neuropsychological test variables whereas type II CLs, deep gray matter lesion volume, and cortical thickness metrics are less frequently associated with cognitive performance.Leukocortical (type I) and subpial (III-IV) CLs identified on 7T FLASH-T2* sequences are potential cortical biomarkers of cognitive and neurologic status in MS. |
| Databáze: | OpenAIRE |
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