Elevated serum progesterone values at the time of ovulation induction in luteal leuprolide acetate-down-regulated GIFT cycles are associated with decreased clinical pregnancy rates
| Autor: | Dian Gantt, Natalie Romines, Michael J. Kirk, Gary W. Randall, Pickens A. Gantt |
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| Rok vydání: | 1996 |
| Předmět: |
Ovulation
endocrine system medicine.medical_specialty Pregnancy Rate medicine.medical_treatment media_common.quotation_subject Down-Regulation Luteal phase Endometrium Chorionic Gonadotropin Human chorionic gonadotropin Pregnancy Internal medicine Genetics medicine Humans Gamete intrafallopian transfer Progesterone Genetics (clinical) media_common business.industry Obstetrics and Gynecology General Medicine medicine.disease Gamete Intrafallopian Transfer Pregnancy rate medicine.anatomical_structure Endocrinology Reproductive Medicine Female Ovulation induction Leuprolide business Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics. 13:459-463 |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/bf02066524 |
| Popis: | The effects of premature luteinization of ovarian follicles as detected by elevated progesterone values on the day of human chorionic gonadotropin induction of ovulation were evaluated in 38 consecutive gamete intrafallopian transfer (GIFT) retrieval cycles.All patients received leuprolide acetate beginning in the midluteal phase of their prior menstrual cycle, followed by gonadotropin stimulation of folliculogenesis. At least four oocytes were transferred in each cycle.No significant differences in gonadotropin dosage, total number of days of gonadotropins, age, number of prior pregnancies, years of infertility since last pregnancy, total number of eggs retrieved, mature residual oocytes, fertilization of mature residual oocytes, or primary etiology of infertility were observed between groups; however, estradiol concentrations were significantly higher in the group with elevated progesterone values (2573 +/- 216 pg/ml) compared to the lower progesterone group (1925 +/- 202 pg/ml, P = 0.035) and the total number of oocytes transferred was greater in the high progesterone group (7.5 +/- 0.5) vs the low progesterone group (6.3 +/- 0.3, P0.038). P4 concentrationsor = 0.8 ng/ml were associated with significantly higher pregnancy rates (11/19; 57.9%) compared to progesterone concentrations0.8 ng/ml (5/19, 26.3%; P = 0.050).Premature luteinization may occur in luteal leuprolide acetate-down-regulated patients and progesterone values0.8 ng/ml are associated with significantly lower pregnancy rates in GIFT cycles. |
| Databáze: | OpenAIRE |
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