Should all patients with unexplained anaemia be screened for chronic lead poisoning?
| Autor: | David M. Wood, M Sculley, Alison L Jones, Ivan House, I B Gawarammana, S Woodcock, Paul I. Dargan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Anemia Health Toxicology and Mutagenesis Toxicology 030226 pharmacology & pharmacy Gastroenterology Lead poisoning Hemoglobins 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine In patient 030212 general & internal medicine Poor correlation Child Aged Aged 80 and over Air Pollutants business.industry Medical screening Infant General Medicine Middle Aged medicine.disease Surgery Lead Poisoning Lead Child Preschool Epidemiological Monitoring Female Normocytic anaemia business Environmental Monitoring |
| Zdroj: | Human & Experimental Toxicology. 25:645-649 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/0960327106074594 |
| Popis: | The global prevalence of lead poisoning is declining. However, the prevalence of lead poisoning in patients with either microcytic or normocytic anaemia is unknown. Blood samples from anaemic patients residing in south-east London without an obvious cause for anaemia had their blood lead concentration (BLC) analysed. A batch of 988 samples was analysed for BLC using atomic absorption spectroscopy. Median haemoglobin was 10.3 g/dL (range: 4.2-10.9) in females, 10.6 g/dL (range: 5.2-11.4) in males and 10.7 g/dL (range: 6.7-10.9) in children. Median BLC was 2.63 microg/dL (0.21-24.0 microg/dL; 95th centile 7.54 microg/dL). Fifteen samples (1.5%) had a BLC10.0 microg/dL, five samples (1%)15.0 microg/dL and one sample (0.1%)20.0 micrg/L. In the 106 children, median BLC was 2.34 microg/dL (0.5-14.5 microg/dL; 95th centile 6.12 microg/ dL). Only one child (14.5 microg/L) had a BLC10.0 pg/dL. There was a poor correlation between haemoglobin and BLC (r2 = 0.08). Routine screening for lead poisoning cannot be justified in all patients with unexplained anaemia, unless there is a history or clinical features to suggest lead toxicity. Additionally, we have shown that in this former high-risk area for lead exposure, there is a low point prevalence of significant lead poisoning, even in an anaemic population. |
| Databáze: | OpenAIRE |
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