The Genetic Diversity of HIV-1 Within Antiretroviral-Naive Outpatients in Ganzhou, China
| Autor: | Bing-Yu Xie, Zhen Huang, Yu-Ning Zhang, Si-Wei Cheng, Yan-Heng Zhou, Da-Qing Zhu, Ying-Na Xie, Xin Chen, Dan-Dan Huang |
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| Rok vydání: | 2021 |
| Předmět: |
China
medicine.medical_specialty Genetic diversity Genotype business.industry Immunology MEDLINE Human immunodeficiency virus (HIV) Genetic Variation virus diseases HIV Infections Sequence Analysis DNA medicine.disease_cause Virology Infectious Diseases Outpatients Epidemiology HIV-1 medicine Antiretroviral naive Humans business Phylogeny |
| Zdroj: | AIDS Research and Human Retroviruses. 37:147-150 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2020.0168 |
| Popis: | To explore the molecular epidemiological status of human immunodeficiency virus type 1 (HIV-1) in Ganzhou, China, eight HIV-1-positive outpatients were recruited from July 5 to 21, 2018. Six HIV-1 near-full-length sequences were amplified and sequenced from the plasma samples that were collected before the patients' antiretroviral treatments. Phylogenetic and bootscan analyses revealed that one of the sequences was CRF01_AE, one was CRF55_01B, and two were CRF07_BC. Notably, one of the sequences was a unique recombinant form, and one of them was a second-generation recombinant form of CRF07_BC and subtype C. These results revealed that multiple HIV-1 subtypes are circulating in Ganzhou, China. Systematic surveys with large sample sizes are urgently needed to explore the exact molecular epidemiological characteristics and to trace the origins of HIV-1 in Ganzhou, China. |
| Databáze: | OpenAIRE |
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