Protective effects of aqueous extract of Hammada scoparia against hepatotoxicity induced by ethanol in the rat
| Autor: | Raoudha Mezghani Jarraya, Abdelfattah Elfeki, Mohamed Damak, Riadh Nciri, Ezzeddine Bourogaa |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Health Toxicology and Mutagenesis Phytochemicals Rat model Toxicology medicine.disease_cause chemistry.chemical_compound In vivo medicine Animals Aspartate Aminotransferases Rats Wistar Aqueous extract Glutathione Peroxidase Amaranthaceae Ethanol Traditional medicine Plant Extracts Superoxide Dismutase Chemistry Body Weight Public Health Environmental and Occupational Health Alanine Transaminase Hammada scoparia Organ Size Alkaline Phosphatase Catalase Rats Plant Leaves Oxidative Stress Liver Biochemistry Lipid Peroxidation Chemical and Drug Induced Liver Injury Oxidative stress |
| Zdroj: | Toxicology and Industrial Health. 30:113-122 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233712452602 |
| Popis: | Aqueous extract (AE) of Hammada scoparia leaves was chemically characterized and its hepatoprotective activities were investigated in vivo in rat model. Wistar rats were treated daily with 35% ethanol solution (3 g/kg/day) during 4 weeks and fed with basal diet or basal diet containing AE (200 mg/kg/day). Control rats were treated with saline solution and fed with basal diet. The bioactivity of AE against ethanol-induced oxidative stress in rat liver was studied in order to explore its hepatoprotective effects. H. scoparia extract used at 200 mg/kg body weight significantly prevented the effects of ethanol, which induced a hepatic pathological damage and increased the levels of the serum markers of the enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). Concomitantly, with these changes, this extract also prevented ethanol-induced oxidative stress in the rat liver as evidenced by the decreased lipid peroxidation level, a considerable decrease in the activities of AST, ALT and ALP and restoring the activities of antioxidant enzymes: superoxide dismutase, catalase and glutathione peroxidase. These biochemical changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the AE of H. scoparia. |
| Databáze: | OpenAIRE |
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