Melanocytoma and meningeal melanocytosis, similar but different lesions
| Autor: | Felipe Padilla-Vázquez, Teresa Cuesta-Mejía, Víctor Hugo Escobar-de la Garma, Arturo Ayala-Arcipreste, Rafael Mendizábal-Guerra |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Neuroimaging Ocean Engineering Meningeal Melanocytosis Malignancy Young Adult 03 medical and health sciences Meninges 0302 clinical medicine Antigens Neoplasm Meningeal Neoplasms Mitotic Index medicine Humans Meningeal Neoplasm Melanoma Paraplegia Meningeal Melanomatosis business.industry Leptomeninges Recovery of Function medicine.disease Magnetic Resonance Imaging Melanosis 030220 oncology & carcinogenesis Melanocytes Female Melanocytoma business Spinal Cord Compression 030217 neurology & neurosurgery |
| Zdroj: | Cirugía y Cirujanos (English Edition). 85:273-278 |
| ISSN: | 2444-0507 |
| Popis: | Background Meningeal melanomatosis is an extra-axial well-encapsulated malignant tumour with diffuse meningeal growth and dark colouration (due to high melanin contents), while meningeal melanocytoma is the focalised benign variant. Melanocytic lesions may be secondary to melanoma or be histologically benign, however, their diffuse nature makes them impossible to cure. Melanocytosis is a diffuse tumour that can form solitary extra-axial tumours, which invades the parenchyma and presents signs of malignancy with increased mitosis and Ki67, observed in 1 to 6% of immunopathological exams. Melanoma of the leptomeninges, presents signs of malignancy with anaplastic cells, which cluster in fascicles of melanin in the cytoplasm, with more than 3 atypical mitoses per field and Ki67 presenting in more than 6% of the immunopathological fields analysed. Clinical case We present the case of a patient with long-term meningeal melanomatosis, with progressive neurologic deficit and characteristic radiologic features, and another case of meningeal melanocytoma. Conclusions Benign melanocytic neoplasms of the central nervous system must be treated aggressively in the early phases with strict follow-up to avoid progression to advanced phases that do not respond to any treatment method. Unfortunately, the prognosis for malignant melanocytic lesions is very poor irrespective of the method of treatment given. |
| Databáze: | OpenAIRE |
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