Aberrations in the arcuate fasciculus are associated with auditory verbal hallucinations in psychotic and in non-psychotic individuals
Autor: | Kelly M. J. Diederen, Iris E. C. Sommer, Sebastiaan F. W. Neggers, René C.W. Mandl, Antoin D. de Weijer, Hilleke E. Hulshoff Pol, René S. Kahn |
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Rok vydání: | 2011 |
Předmět: |
Male
Hallucinations Nerve Fibers Myelinated behavioral disciplines and activities Brain mapping White matter Fractional anisotropy Image Processing Computer-Assisted medicine Humans Arcuate fasciculus Radiology Nuclear Medicine and imaging Research Articles Analysis of Variance Brain Mapping Radiological and Ultrasound Technology Cognition medicine.disease Magnetic Resonance Imaging Temporal Lobe Frontal Lobe Diffusion Tensor Imaging medicine.anatomical_structure Psychotic Disorders Neurology Schizophrenia Hallucinating Female Neurology (clinical) Nerve Net Anatomy Psychology Neuroscience Diffusion MRI |
Zdroj: | Hum Brain Mapp |
ISSN: | 1065-9471 |
Popis: | The pathophysiology of auditory verbal hallucinations (AVH) is still unclear. Cognitive as well as electrophysiological studies indicate that a defect in sensory feedback (corollary discharge) may contribute to the experience of AVH. This could result from disruption of the arcuate fasciculus, the major tract connecting frontal and temporo‐parietal language areas. Previous diffusion tensor imaging studies indeed demonstrated abnormalities of this tract in schizophrenia patients with AVH. It is, however, difficult to disentangle specific associations with AVH in this patient group as many other factors, such as other positive and negative symptoms, medication or halted education could likewise have affected tract integrity. We therefore investigated AVH in relative isolation and studied a group of non‐psychotic individuals with AVH as well as patients with AVH and non‐hallucinating matched controls. We compared tract integrity of the arcuate fasiculus and of three other control tracts, between 35 non‐psychotic individuals with AVH, 35 schizophrenia patients with AVH, and 36 controls using diffusion tensor imaging and magnetization transfer imaging. Both groups with AVH showed an increase in magnetization transfer ratio (MTR) in the arcuate fasciculus, but not in the other control tracts. In addition, a general decrease in fractional anisotropy (FA) for almost all bundles was observed in the patient group, but not in the non‐psychotic individuals with AVH. As increased MTR in the arcuate fasciculus was present in both hallucinating groups, a specific association with AVH seems plausible. Decreases in FA, on the other hand, seem to be related to other disease processes of schizophrenia. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc. |
Databáze: | OpenAIRE |
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