Prognostic Value of Preoperative Serum CA 242 in Esophageal Squamous Cell Carcinoma Cases
| Autor: | Ying Huang, Qi-Xun Chen, Ji-Feng Feng |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Multivariate analysis Esophageal Neoplasms Epidemiology Esophageal squamous cell carcinoma Gastroenterology Internal medicine Preoperative Care Biomarkers Tumor Retrospective analysis Humans Medicine Antigens Tumor-Associated Carbohydrate Aged Neoplasm Staging Retrospective Studies Tumor marker Receiver operating characteristic business.industry Public Health Environmental and Occupational Health Middle Aged Esophageal cancer Prognosis medicine.disease Predictive factor Survival Rate ROC Curve CA 242 Carcinoma Squamous Cell Female Neoplasm Grading business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 14:1803-1806 |
| ISSN: | 1513-7368 |
| Popis: | Purpose: Carbohydrate antigen (CA) 242 is inversely related to prognosis in many cancers. However, few data regarding CA 242 in esophageal cancer (EC) are available. The aim of this study was to determine the prognostic value of CA 242 and propose an optimum cut-off point in predicting survival difference in patients with esophageal squamous cell carcinoma (ESCC). Methods: A retrospective analysis was conducted of 192 cases. A receiver operating characteristic (ROC) curve for survival prediction was plotted to verify the optimum cufoff point. Univariate and multivariate analyses were performed to evaluate prognostic parameters for survival. Results: The positive rate for CA 242 was 7.3% (14/192). The ROC curve for survival prediction gave an optimum cut-off of 2.15 (U/ml). Patients with CA 242 ≤ 2.15 U/ml had significantly better 5-year survival than patients with CA 242 >2.15 U/ml (45.4% versus 22.6%; P=0.003). Multivariate analysis showed that differentiation (P=0.033), CA 242 (P=0.017), T grade (P=0.004) and N staging (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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