Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study
| Autor: | Eva García-Escobar, Luis Castaño, Sergio Valdés, Juan Girbés, Elías Delgado, Cristina Maldonado-Araque, Josep Franch-Nadal, Alfonso Calle, Felipe J. Chaves, Sonia Gaztambide, Sara García-Serrano, Silvia Patricia Alonso, Gemma Rojo-Martínez, Pilar Ocon, Edelmiro Menéndez, Ana Lago, Gabriel Olveira, Natalia Colomo, José Carlos Fernández-García |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Thyroid Hormone Resistance Syndrome medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Population Comorbidity Thyroid Function Tests Young Adult Endocrinology Risk Factors Internal medicine medicine Risk of mortality Health Status Indicators Humans Euthyroid Longitudinal Studies education Aged Aged 80 and over education.field_of_study business.industry Thyroid disease Thyroid Patient Acuity General Medicine Middle Aged medicine.disease Thyroid hormone resistance medicine.anatomical_structure Spain Asymptomatic Diseases Population study Female Independent Living business Hormone |
| Popis: | Objective It has been proposed that a mild form of acquired resistance to thyroid hormone may occur in the general population. Its clinical significance remains largely unknown. The objective of the study was to explore whether a newly described thyroid hormone resistance index is associated with the risk of mortality in a sample of community-dwelling euthyroid subjects representative of the adult population of Spain. Design Longitudinal observational study including 3750 individuals, free of thyroid disease, TPO antibodies-negative ( Methods We used the Thyroid Feedback Quantile-based Index (TFQI) as a marker of resistance to thyroid hormone. The study population was grouped into categories according to their TFQI values at baseline. Fatal events were ascertained from the national death registry (end of follow-up December 2016). Results A total of 231 deaths were recorded during an average follow-up of 7.3 years. Compared with the category with the highest sensitivity to free thyroxine (TFQI ≤ p5) (reference), the relative risk of mortality in the categories with TFQI > p5 and ≤p25; >p25 and ≤p50; >p50 and ≤p75; >p75 and ≤p95 and >p95 were 1.01, (0.47–2.19), 1.42 (0.68–2.97), 1.54 (0.74–3.22), 1.47 (0.70–3.11) and 2.61 (1.16–5.89), respectively (P for trend 0.003). The association remained significant after multivariate adjustment of the data (P for trend 0.017). Conclusions A thyroid hormone resistance index focused on deviations of the average pituitary response to thyroid hormones may be associated with all-cause mortality independently of other conventional risk factors and comorbidities. |
| Databáze: | OpenAIRE |
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