Cellular migration, proliferation, and contraction. An in vitro approach to a clinical problem--proliferative vitreoretinopathy
| Autor: | Nino Sorgente, Stephen J. Ryan, Gavin Orr, Victor W. Renardel de Lavalette, Jose Dalma-Weizhausz, Cornelis Verdoorn |
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| Rok vydání: | 1986 |
| Předmět: |
Proliferative vitreoretinopathy
Contraction (grammar) Paclitaxel Cytochalasin B Cell Biology Pharmacology Retina chemistry.chemical_compound Alkaloids Retinal Diseases medicine Colchicine Animals Cytochalasin Cells Cultured Skin Cell growth Chemotaxis Daunorubicin Cell migration Fibroblasts medicine.disease Ophthalmology medicine.anatomical_structure chemistry Immunology Rabbits Cell Division |
| Zdroj: | Archives of ophthalmology (Chicago, Ill. : 1960). 104(8) |
| ISSN: | 0003-9950 |
| Popis: | • Presently used animal models of proliferative vitreoretinopathy reflect only cell proliferation and contraction. We used an in vitro model that measured cell migration, proliferation, and contraction. The following four drugs were assayed on this system: daunomycin, taxol, colchicine, and cytochalasin B. Daunomycin was the most effective drug against cell proliferation and cell migration but had no effect on cell contraction; taxol and colchicine affected all three parameters. Cytochalasin B was the least effective drug tested. |
| Databáze: | OpenAIRE |
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