A current and historical perspective on disparities in US childhood pneumococcal conjugate vaccine adherence and in rates of invasive pneumococcal disease: Considerations for the routinely-recommended, pediatric PCV dosing schedule in the United States
| Autor: | Edward Power, John M McLaughlin, Verna L. Welch, Nina M Hill, Eric A Utt, Gregg C Sylvester |
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| Rok vydání: | 2015 |
| Předmět: |
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Pediatrics medicine.medical_specialty Pneumococcal disease Immunology Disease complex mixtures Pneumococcal conjugate vaccine Health Services Accessibility Pneumococcal Infections Medication Adherence Pneumococcal Vaccines 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Commentaries medicine Immunology and Allergy Humans 030212 general & internal medicine Dosing Healthcare Disparities Socioeconomic status Immunization Schedule Pharmacology Vaccines Conjugate business.industry Infant medicine.disease United States Pneumococcal infections pneumococcal conjugate vaccine (PCV) adherence coverage dosing schedule disparities race minorities socioeconomic status pneumococcal disease 2+1 3+1 Child Preschool Dose reduction business medicine.drug |
| Zdroj: | Human Vaccines & Immunotherapeutics |
| ISSN: | 2164-554X |
| Popis: | Previous research has suggested that reducing the US 4-dose PCV13 schedule to a 3-dose schedule may provide cost savings, despite more childhood pneumococcal disease. The study also stressed that dose reduction should be coupled with improved PCV adherence, however, US PCV uptake has leveled-off since 2008. An estimated 24–36% of US children aged 5–19 months are already receiving a reduced PCV schedule (i.e., missing ≥1 dose). This raises a practical concern that, under a reduced, 3-dose schedule, a similar proportion of children may receive ≤2 doses. It is also unknown if a reduced, 3-dose PCV schedule in the United States will afford the same disease protection as 3-dose schedules used elsewhere, given lower US PCV adherence. Finally, more assurance is needed that, under a reduced schedule, racial, socioeconomic, and geographic disparities in PCV adherence will not correspond with disproportionately higher rates of pneumococcal disease among poor or minority children. |
| Databáze: | OpenAIRE |
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