Schizophrenia Exhibits Bi-Directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits
| Autor: | Jie Lisa Ji, Genevieve Yang, Caroline Diehl, John A. Sweeney, Grega Repovs, John D. Murray, Brett A. Clementz, S. Kristian Hill, Anderson M. Winkler, Carol A. Tamminga, John H. Krystal, Gina Creatura, Matcheri S. Keshavan, Godfrey D. Pearlson, Alan Anticevic, Charles Schleifer |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cerebellum Cognitive Neuroscience Thalamus Striatum Biology Cellular and Molecular Neuroscience 03 medical and health sciences 0302 clinical medicine Neural Pathways medicine Humans In patient Effects of sleep deprivation on cognitive performance Cerebral Cortex Brain Mapping Resting state fMRI medicine.diagnostic_test Functional connectivity Brain Original Articles Magnetic Resonance Imaging Corpus Striatum 030227 psychiatry medicine.anatomical_structure Cerebral cortex Schizophrenia Chronic schizophrenia Female Psychology Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cereb Cortex |
| DOI: | 10.1101/166728 |
| Popis: | Distributed neural dysconnectivity is considered a hallmark feature of schizophrenia, yet a tension exists between studies pinpointing focal disruptions versus those implicating brain-wide disturbances. The cerebellum and the striatum communicate reciprocally with the thalamus and cortex through monosynaptic and polysynaptic connections, forming cortico-striatal-thalamic-cerebellar (CSTC) functional pathways that may be sensitive to brain-wide dysconnectivity in schizophrenia. It remains unknown if the same pattern of alterations persists across CSTC systems, or if specific alterations exist along key functional elements of these networks. We characterized connectivity along major functional CSTC subdivisions using resting-state functional magnetic resonance imaging in 159 chronic patients and 162 matched controls. Associative CSTC subdivisions revealed consistent brain-wide bi-directional alterations in patients, marked by hyper-connectivity with sensory-motor cortices and hypo-connectivity with association cortex. Focusing on the cerebellar and striatal components, we validate the effects using data-driven k-means clustering of voxel-wise dysconnectivity and support vector machine classifiers. We replicate these results in an independent sample of 202 controls and 145 patients, additionally demonstrating that these neural effects relate to cognitive performance across subjects. Taken together, these results from complementary approaches implicate a consistent motif of brain-wide alterations in CSTC systems in schizophrenia, calling into question accounts of exclusively focal functional disturbances. |
| Databáze: | OpenAIRE |
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