Sequential therapy compared with standard triple therapy for Helicobacter pylori eradication in children: a double-blind, randomized, controlled trial
| Autor: | Piotr Albrecht, Hania Szajewska, Maria Kotowska |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Urea breath test Rapid urease test Gastroenterology Drug Administration Schedule Tinidazole law.invention Helicobacter Infections Randomized controlled trial Anti-Infective Agents Double-Blind Method law Clarithromycin Internal medicine medicine Humans Urea Omeprazole Breath test Carbon Isotopes biology medicine.diagnostic_test business.industry Amoxicillin Proton Pump Inhibitors Helicobacter pylori biology.organism_classification Surgery Breath Tests Pediatrics Perinatology and Child Health Drug Therapy Combination Female business medicine.drug |
| Zdroj: | The Journal of pediatrics. 159(1) |
| ISSN: | 1097-6833 |
| Popis: | Objective To determine the effectiveness of sequential therapy compared with standard triple therapy for Helicobacter pylori eradication in children. Study design In 107 children with H pylori infection confirmed with 2 of 3 tests ( 13 C-urea breath test, histopathology, rapid urease test), we conducted a double-blind, randomized, controlled trial comparing a sequential treatment (amoxicillin and omeprazole for 5 days followed by clarithromycin, tinidazole, and omeprazole for 5 days) to a 7-day standard triple eradication regimen (amoxicillin and clarithromycin plus omeprazole) followed by placebo for 3 days. Results In the experimental group (n = 52) compared with the control group (n = 51), there was a significant difference in the H pylori eradication rate at 6 to 8 weeks after the completion of treatment (primary outcome), as confirmed with negative results on 13 C-urea breath test (45/52 or 86.5% versus 35/51 or 68.6%; relative risk, 1.26; 95% CI, 1.02-1.60). Groups did not differ in any of the secondary outcomes (ie, adverse effects, the need for discontinuation of the H pylori therapy, compliance with therapy). Conclusions In children with H pylori infection, sequential eradication therapy compared with standard triple therapy resulted in a higher eradication rate, although the difference was of borderline statistical significance. |
| Databáze: | OpenAIRE |
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