Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study

Autor: Leurs, CE, Twaalfhoven, HAM, Lissenberg-Witte, BI, van Pesch, V, Dujmovic, I, Drulovic, J, Castellazzi, M, Bellini, T, Pugliatti, M, Kuhle, J, Villar, LM, Alvarez-Cermeño, JC, Alvarez-Lafuente, R, Hegen, H, Deisenhammer, F, Walchhofer, LM, Thouvenot, E, Comabella, M, Montalban, X, Vécsei, L, Rajda, C, Galimberti, D, Scarpini, E, Altintas, A, Rejdak, K, Frederiksen, JL, Pihl-Jensen, G, Jensen, PEH, Khalil, M, Voortman, MM, Fazekas, F, Saiz, Albert, La Puma, D, Vercammen, M, Vanopdenbosch, L, Uitdehaag, BMJ, Killestein, J, Bridel, C, Teunissen, Charlotte E, Universitat Autònoma de Barcelona
Přispěvatelé: UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurologie, Basic (bio-) Medical Sciences, Ayşe, Altıntaş, Leurs, C.E., Twaalfhoven, H.A.M., Lissenberg-Witte, B.I., van Pesch, V., Dujmovic, I., Drulovic, J., Castellazzi, M., Bellini, T., Pugliatti, M., Kuhle, J., Villar, L.M., Alvarez-Cermeño, J.C., Alvarez-Lafuente, R., Hegen, H., Deisenhammer, F., Walchhofer, L.M., Thouvenot, E., Comabella, M., Montalban, X., Vécsei, L., Rajda, C., Galimberti, D., Scarpini, E., Rejdak, K., Frederiksen, J.L., Pihl-Jensen, G., Jensen, P.E.H., Khalil, M., Voortman, M.M., Fazekas, F., Saiz, A., La Puma, D., Vercammen, M., Vanopdenbosch, L., Uitdehaag, B.M.J., Killestein, J., Bridel, C., Teunissen, C., School of Medicine, Department of Neurology, Neurology, Laboratory Medicine, Epidemiology and Data Science, APH - Methodology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Department of Anatomy and Neurosciences [Amsterdam, The Netherlands] (Amsterdam Neuroscience), Section Clinical Neuroanatomy [Amsterdam, The Netherlands], VU University Medical Center [Amsterdam]-VU University Medical Center [Amsterdam], Vrije Universiteit Medical Centre (VUMC), Vrije Universiteit Amsterdam [Amsterdam] (VU), Cliniques Universitaires Saint-Luc [Bruxelles], Clinical Centre of Serbia, Università degli Studi di Ferrara (UniFE), University Hospital Basel [Basel], Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Red Española de Esclerosis Múltiple (REEM), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Department of Neurology, Medical University of Innsbruck, Service de Neurologie [CHU Nimes] (Pôle NIRR), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Centre d'Esclerosi Múltiple de Catalunya (CemCat), Vall d'Hebron University Hospital [Barcelona], Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University of Szeged [Szeged], Centro Dino Ferrari [Milano], Università degli Studi di Milano [Milano] (UNIMI)-Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Koç University, Medical University of Lublin, Rigshospitalet [Copenhagen], Copenhagen University Hospital, Danish Multiple Sclerosis Research Centre, Copenhagen University Hospital-Copenhagen University Hospital, Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz 8010, Austria, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Department of Neurology, AZ Sint Jan Brugge Oostende, Neuroscience Amsterdam, VU University Medical Centre, 1081HV 1117, Amsterdam, Amsterdam Neuroscience [Pays-Bas], Vrije Universiteit Amsterdam [Amsterdam] (VU)-University of Amsterdam [Amsterdam] (UvA)-VU University Medical Center [Amsterdam]
Jazyk: angličtina
Rok vydání: 2020
Předmět:
KFLC (kappa free light chain)
Adult
Male
Multiple Sclerosis
Clinical Neurology
Esclerosi múltiple
CSF
CSF (cerebrospinal fluid)
Immunoglobulin light chain
Sensitivity and Specificity
NO
Multiple sclerosis
Immunoglobulin kappa-Chains
03 medical and health sciences
0302 clinical medicine
Nuclear magnetic resonance
Immunoglobulin lambda-Chains
Humans
Medicine
Diagnostic biomarker
biomarkers
KFLC
OCB
030304 developmental biology
0303 health sciences
business.industry
Biochemical markers
Oligoclonal Bands
Reproducibility of Results
Middle Aged
OCB (oligoclonal IgG band)
Free Light Chain
Biomarkers
Neurology
Multicenter study
Marcadors bioquímics
[SDV.IMM]Life Sciences [q-bio]/Immunology
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Female
Neurology (clinical)
business
Original Research Papers
030217 neurology & neurosurgery
Kappa
Zdroj: Leurs, C E, Twaalfhoven, H A M, Lissenberg-Witte, B I, van Pesch, V, Dujmovic, I, Drulovic, J, Castellazzi, M, Bellini, T, Pugliatti, M, Kuhle, J, Villar, L M, Alvarez-Cermeño, J C, Alvarez-Lafuente, R, Hegen, H, Deisenhammer, F, Walchhofer, L M, Thouvenot, E, Comabella, M, Montalban, X, Vécsei, L, Rajda, C, Galimberti, D, Scarpini, E, Altintas, A, Rejdak, K, Frederiksen, J L, Pihl-Jensen, G, Jensen, P E H, Khalil, M, Voortman, M M, Fazekas, F, Saiz, A, la Puma, D, Vercammen, M, Vanopdenbosch, L, Uitdehaag, B M J, Killestein, J, Bridel, C & Teunissen, C 2020, ' Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study ', Multiple Sclerosis Journal, vol. 26, no. 8, pp. 912-923 . https://doi.org/10.1177/1352458519845844
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Multiple Sclerosis (Houndmills, Basingstoke, England)
Multiple sclerosis, Vol. 26, no. 8, p. 912-923 (2020)
Multiple Sclerosis Journal
Leurs, C E, Twaalfhoven, H A M, Lissenberg-Witte, B I, van Pesch, V, Dujmovic, I, Drulovic, J, Castellazzi, M, Bellini, T, Pugliatti, M, Kuhle, J, Villar, L M, Alvarez-Cermeño, J C, Alvarez-Lafuente, R, Hegen, H, Deisenhammer, F, Walchhofer, L M, Thouvenot, E, Comabella, M, Montalban, X, Vécsei, L, Rajda, C, Galimberti, D, Scarpini, E, Altintas, A, Rejdak, K, Frederiksen, J L, Pihl-Jensen, G, Jensen, P E H, Khalil, M, Voortman, M M, Fazekas, F, Saiz, A, La Puma, D, Vercammen, M, Vanopdenbosch, L, Uitdehaag, B M J, Killestein, J, Bridel, C & Teunissen, C 2020, ' Kappa free light chains is a valid tool in the diagnostics of MS : A large multicenter study ', Multiple Sclerosis Journal, vol. 26, no. 8, pp. 912-923 . https://doi.org/10.1177/1352458519845844
Multiple Sclerosis Journal, 26(8), 912-923. SAGE Publications Ltd
Dipòsit Digital de la UB
Universidad de Barcelona
Multiple Sclerosis Journal, SAGE Publications, 2020, 26 (8), pp.912-923. ⟨10.1177/1352458519845844⟩
ISSN: 1352-4585
1477-0970
Popis: Objective: to validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: we performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: the cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2–138.1). The cut-off for the LFLC index was 6.9 (95% CI = 4.5–22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85–0.90) was higher than OCB (0.82; 95%CI = 0.79–0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78–0.88) was lower (OCB = 0.92; 95% CI = 0.89–0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS.
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Databáze: OpenAIRE
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