Therapeutic Efficacy and Inhibitory Mechanism of Regorafenib Combined With Radiation in Colorectal Cancer
| Autor: | Chih-Hung Chiang, Yu-Chang Liu, Jing Gung Chung, I-Tsang Chiang, Fei-Ting Hsu, Song Shei Lin, Yuan-Hao Lee, Mao-Chi Weng, Jung-Hung Hsieh, Cheng-Shyong Chang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Radiosensitizer Colorectal cancer Pyridines medicine.medical_treatment Apoptosis General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Regorafenib Internal medicine Cell Line Tumor medicine Animals Humans Pharmacology Chemotherapy Mechanism (biology) business.industry Phenylurea Compounds NF-kappa B NF-κB medicine.disease Xenograft Model Antitumor Assays Radiation therapy chemistry 030220 oncology & carcinogenesis business Colorectal Neoplasms Research Article |
| Zdroj: | In Vivo |
| Popis: | Background Although both chemotherapy and radiotherapy (RT) can sufficiently maintain tumor suppression of colorectal cancer (CRC), these treatments may trigger the expression of nuclear factor kappa B (NF-κB) and compromise patients' survival. Regorafenib suppresses NF-κB activity in various tumor types. However, whether regorafenib may act as a suitable radiosensitizer to enhance therapeutic efficacy of RT remains unknown. Materials and methods Here, we established a CRC-bearing animal model to investigate the therapeutic efficacy of regorafenib in combination with RT, through measurement of tumor growth, body weight, whole-body computed tomography (CT) scan and immunohisto-chemistry staining. Results Smallest tumor size and weight were found in the combination treatment group. In addition, RT-induced up-regulation of NF-κB and downstream proteins were diminished by regorafenib. Moreover, the body weight and liver pathology in the treated group were similar to those of the non-treated control group. Conclusion Regorafenib may enhance the anti-CRC efficacy of RT. |
| Databáze: | OpenAIRE |
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