Evaluation of markers of bone and collagen turnover in patients with active and preclinical Cushing's syndrome and in patients with adrenal incidentaloma
| Autor: | Bruno Ambrosi, Salvatore Giambona, S. Ferrero, E. Passini, Alessandro Sartorio, T. Re, Antonio Conti |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Adrenal Gland Neoplasms Bone and Bones Bone remodeling Cushing syndrome Endocrinology N-terminal telopeptide Internal medicine Blood plasma Humans Medicine Cushing Syndrome Aged Extracellular Matrix Proteins biology business.industry Incidentaloma Calcium-Binding Proteins General Medicine Middle Aged medicine.disease Procollagen peptidase Adrenocortical Adenoma Osteocalcin biology.protein Female Collagen business Biomarkers Type I collagen |
| Zdroj: | European Journal of Endocrinology. :146-152 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1380146 |
| Popis: | Although steroid-induced negative effects on bone and collagen have been well described in corticosteroid-treated patients, few studies have extensively evaluated bone and collagen turnover in patients with endogenous Cushing's syndrome. In this work serum bone-Gla protein (BGP), C-terminal cross-linked telopeptide of type I collagen (ICTP) and N-terminal propeptide of type III procollagen (PIIINP) levels were determined in patients with active (n = 12) and preclinical (n = 6) Cushing's syndrome, adrenal incidentalomas (n = 35) and in healthy controls (n = 28). In patients with overt Cushing's syndrome, serum BGP (0.9+/-0.2 ng/ml), ICTP (2.7+/-0.2 ng/ml) and PIIINP (1.9+/-0.2 ng/ml) levels were significantly lower (P < 0.0001) than in controls (5.5+/-0.2, 3.9+/-0.2 and 3.2+/-0.2 ng/ml respectively). In preclinical Cushing's syndrome, serum BGP (2.5+/-0.8 ng/ml), ICTP (2.2+/-0.1 ng/ml) and PIIINP (2.2+/-0.2 ng/ml) levels were significantly lower than in normal subjects (P < 0.0001, P < 0.0001 and P < 0.02 respectively), being similar to those recorded in overt Cushing's syndrome. In patients with adrenal incidentaloma, serum BGP (4.2+/-0.5 ng/ml) and ICTP (2.9+/-0.2 ng/ml) levels were significantly lower than those found in controls (P < 0.05 and P < 0.001 respectively), while serum PIIINP levels (3.6+/-0.2 ng/ml) did not differ from those of normals. In particular, 9/35 patients with adrenal incidentaloma had markedly depressed BGP levels ( |
| Databáze: | OpenAIRE |
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