cAMP-dependent phosphorylation of microtubule-associated protein-2 during treatment of sodium valproate and audiogenic kindling
| Autor: | T. G. Shchipakina, T. A. Savina |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Microtubule-associated protein medicine.medical_treatment Hippocampus General Biochemistry Genetics and Molecular Biology Epilepsy Reflex Microtubule-associated protein 2 Internal medicine medicine Cyclic AMP Premovement neuronal activity Phosphorylation Valproic Acid Analysis of Variance Chemistry General Medicine Cyclic AMP-Dependent Protein Kinases Enzyme Activation Anticonvulsant Endocrinology Anticonvulsants Neuroscience Microtubule-Associated Proteins Protein Processing Post-Translational Ex vivo medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 152(1) |
| ISSN: | 1573-8221 |
| Popis: | Administration of anticonvulsant sodium valproate alleviated audiogenic seizures in Krushinskii-Molodkina rats, which was accompanied by a decrease in cAMP-dependent phosphorylation of microtubule-associated protein MAP2 in the hippocampus ex vivo. In contrast, audiogenic kindling resulted in a marked increase in MAP2 phosphorylation at cAMP-dependent protein kinase-specific sites. These changes in the state of MAP2 phosphorylation providing restructuring of dendrites in response to specific influences modulate neuronal activity and are the important mechanisms of neuronal plasticity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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