Epidemiology of NMOSD in Catalonia: Influence of the new 2015 criteria in incidence and prevalence estimates
| Autor: | Cristina Ramo-Tello, Georgina Arrambide, Sergio Martínez-Yélamos, Nuria Sola-Valls, Albert Saiz, Maria Alba Mañé-Martínez, Antonio Escartin, L Romero-Pinel, Nicolau Ortiz, Susana Otero-Romero, Xavier Montalban, Emili Vela, Javier Sotoca, Luis Brieva, Mariona Hervás, Jaume Sastre-Garriga, Yolanda Blanco, Raul Pelayo, Mar Tintoré, Maria Sepúlveda, L. Gubieras, Thaís Armangue, René Robles-Cedeño, Sara Llufriu, Lluís Ramió-Torrentà, Antonio Cano, Francesc Graus, Elvira Munteis, Silvia Presas-Rodríguez, Marta Aldea, Domingo Escudero |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male AQP4-antibodies Malalties rares (Catalunya) medicine.medical_specialty Pediatrics Adolescent prevalence Population MOG-antibodies Young Adult 03 medical and health sciences Neuromyelitis optica spectrum disorders 0302 clinical medicine Epidemiology Prevalence medicine Humans 030212 general & internal medicine Child education Aged Autoantibodies Retrospective Studies education.field_of_study incidence business.industry Incidence Incidence (epidemiology) Multiple sclerosis Neuromyelitis Optica Middle Aged medicine.disease Neurology Neuromyelitis Optica Spectrum Disorders Immunoglobulin G Female Myelin-Oligodendrocyte Glycoprotein Neurology (clinical) Immunoglobulines business 030217 neurology & neurosurgery |
| Zdroj: | MULTIPLE SCLEROSIS JOURNAL r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu Multiple Sclerosis Journal r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| ISSN: | 1352-4585 |
| Popis: | Background: Population-based studies on neuromyelitis optica spectrum disorders (NMOSD) are limited, and it is unclear whether the rates have changed with the implementation of the new 2015 criteria. Objectives: To estimate the incidence and prevalence of NMOSD in Catalonia (Spain), using both the 2006 and the 2015 criteria. Methods: In this clinic-based retrospective study, patients diagnosed with NMOSD between 2006 and 2015 were identified using multiple sources, including direct contact to all Catalan hospitals, identification of cases through the Catalan Health Surveillance System, and registry of antibodies to aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) in a reference laboratory. The incidence rate was calculated for the period 1 January 2006–1 January 2016 and prevalence for the date 1 January 2016. Results: We identified 74 patients (by the 2015 criteria). Most patients were Caucasian (81%), and female (76%) with a median age at disease onset of 42 years (range, 10–76 years). In total, 54 (73%) patients were positive for AQP4-IgG, 11 (15%) double-seronegative, and 9 (12%) MOG-IgG-positive. Rates of incidence and prevalence (0.63/1,000,000 person-years and 0.89/100,000, respectively) were 1.5-fold higher than those reported by the 2006 criteria. Lowest rates were seen in children and elder people and highest in women and middle-aged people (40–59 years). The female predominance was lost in incident AQP4-IgG-seronegative children and AQP4-IgG-positive elder people. MOG-IgG and double-seronegativity contributed similarly but did not influence the long-term outcome. Conclusion: The new criteria increase the estimates, but NMOSD remains as a rare disease. The differences in age- and sex-specific estimates highlight the importance of the serologic classification. |
| Databáze: | OpenAIRE |
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