Cortisol Secretion Rate, ACTH and Methopyrapone Tests in High Altitude Native Residents
| Autor: | Federico Moncloa, Eduardo Pretell |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Cortisol secretion
endocrine system medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Clinical Biochemistry Stimulation Urine Biochemistry Excretion Endocrinology Altitude Adrenocorticotropic Hormone Internal medicine medicine Mineralocorticoid Receptor Antagonists 17-Hydroxycorticosteroids Pharmacology Metyrapone business.industry Biochemistry (medical) Ketones Effects of high altitude on humans 17-Ketosteroids Body Fluids Metabolism Methopyrapone business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 24:915-918 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-24-9-915 |
| Popis: | The cortisol secretion rate and the response to ACTH stimulation and to methopyrapone have been studied in high altitude native residents in comparison with a similar group of men living at sea level. No differences were found in the cortisol secretion rate, in the stimulation with 20 U of ACTH and in the response to methopyrapone administration. However, with 1 U of ACTH the high altitude group had a lower excretion of 17-ketosteroids and 17-hydroxycorticosteroids. In view of these results it may be postulated that high altitude natives need a greater ACTH production to maintain a cortisol secretion rate similar to the one observed in the sea level group. A possible explanation for the lower response to 1 U of ACTH in high altitude natives, but a normal one to 20 U of ACTH, is offered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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