Progress in studies of epidermal stem cells and their application in skin tissue engineering
Autor: | Xiaodong Chen, Xi-Min Hu, Shuai Yang, Jingling Zhao, Kun Xiong, Jingru Wang, Julin Xie, Ronghua Yang |
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Rok vydání: | 2020 |
Předmět: |
Cell
Population EPSC-dermal interaction Medicine (miscellaneous) Review Biology Biochemistry Genetics and Molecular Biology (miscellaneous) lcsh:Biochemistry Tissue engineering Skin tissue medicine Animals lcsh:QD415-436 education Skin tissue engineering Skin lcsh:R5-920 education.field_of_study integumentary system Tissue Engineering musculoskeletal neural and ocular physiology Stem Cells Cell Biology Epidermal stem cells Cell biology Skin regeneration medicine.anatomical_structure nervous system Epidermal Cells Molecular Medicine Epidermis Stem cell lcsh:Medicine (General) Wound healing Homeostasis |
Zdroj: | Stem Cell Research & Therapy Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2020) |
ISSN: | 1757-6512 |
Popis: | The epidermis, which is the outermost layer of mammalian skin, provides an essential barrier that is essential for maintenance of life. The epidermis is a stratified epithelium, which is maintained by the proliferation of epidermal stem cells (EPSCs) at the basal layer of the epidermis. As a unique cell population characterized by self-renewal and differentiation capabilities, EPSCs ensure the maintenance of adult skin homeostasis and participate in repair of the epidermis after injury. Recently, the utilization of EPSCs for wound healing and tissue regeneration has been attracting increased attention from researchers. In addition, the advances in tissue engineering have increased the interest in applying EPSCs in tissue-engineered scaffolds to further reconstitute injured tissues. In this review, we introduce research developments related to EPSCs, including methods recently used in the culture and enrichment of EPSCs, as well as advanced tools to study EPSCs. The function and mechanism of the EPSC-dermal units in the development and homeostasis of the skin are also summarized. Finally, the potential applications of EPSCs in skin tissue engineering are discussed. |
Databáze: | OpenAIRE |
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