Partial breast irradiation with interstitial high-dose-rate brachytherapy in early breast cancer: Results of a phase II prospective study
| Autor: | Paolo Latini, Antonio Rulli, A. Cavalli, C. Raymondi, F. Cucciarelli, Antonio Cavaliere, Roberto Tarducci, Elisabetta Perrucci, Cynthia Aristei, Isabella Palumbo |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Brachytherapy Breast Neoplasms Breast cancer Partial breast irradiation medicine Adjuvant therapy Humans Fat necrosis Prospective Studies Aged Neoplasm Staging Aged 80 and over business.industry Radiotherapy Planning Computer-Assisted Conservative surgery Partial Breast Irradiation Dose-Response Relationship Radiation General Medicine Perioperative Middle Aged medicine.disease High-Dose Rate Brachytherapy Acute toxicity Surgery Treatment Outcome Oncology High-dose-rate brachytherapy Female Tomography X-Ray Computed business Follow-Up Studies |
| Zdroj: | European Journal of Surgical Oncology (EJSO). 35:144-150 |
| ISSN: | 0748-7983 |
| Popis: | Aim To investigate, in a phase II prospective study, the efficacy of partial breast irradiation administered with high-dose-rate brachytherapy. Methods After conservative surgery 80 patients with low-risk early-stage breast cancer received 4Gy twice a day for 4days (total dose 32Gy). Catheter implantation was performed during surgery in 15 cases and postoperatively, at a median of 8weeks from surgery, in 65 patients. Adjuvant therapy was chemotherapy (8) and/or hormone therapy (61). Results Cosmetic results were good/excellent in 79 patients. Perioperative toxicity was very low. Acute skin toxicity developed in seven cases (six G1; one G2); late G3 cutaneous toxicity in one patient and late subcutaneous toxicity in five (three G1; two G2). Grade 1 teleangiectasia occurred in eight patients and grade 2 in one. Fat necrosis was symptomatic in one patient and asymptomatic in five. Only one patient presented pain after brachytherapy. A significantly ( p =0.001) higher frequency of late toxicity was observed in patients implanted during surgery, the group, which included the only patient with a fair cosmetic result. No local or regional relapses have occurred to date. The median follow-up was 30months (range 3–52). Conclusion This strategy is a viable option in selected patients with early-stage breast cancer as it is feasible, reproducible and associated with very low perioperative and acute toxicity. The low incidence of late side effects will probably change as follow-up lengthens. |
| Databáze: | OpenAIRE |
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