Transfer of clarithromycin to gastric juice is enhanced by omeprazole in Hericobacter pylori infected individuals
| Autor: | H. Piovesana, Maristela Deguer, Fernanda E. Dias, G. De Nucci, Fabiana D. Mendes, Amanda Aureliano Pereira, Alexandra Bento, Rodrigo A. Ortiz, J. G. P. Ferraz, José Pedrazzoli, F. E. Lerner, Silvana A. Calafatti |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Spirillaceae Biological Transport Active Gastroenterology Helicobacter Infections Pharmacokinetics Oral administration Clarithromycin Internal medicine medicine Humans Chromatography High Pressure Liquid Omeprazole Antibacterial agent Cross-Over Studies Gastric Juice Helicobacter pylori biology Hepatology business.industry Drug Synergism Anti-Ulcer Agents biology.organism_classification Crossover study Anti-Bacterial Agents business medicine.drug |
| Zdroj: | Publons |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/s0016-5085(00)84122-0 |
| Popis: | The effects of proton-pump inhibitors and Helicobacter pylori infection on the distribution of drugs employed for the eradication of H. pylori are poorly understood. The aim of this study was to investigate the effects of a 7-day oral administration of 20 mg omeprazole on the distribution of clarithromycin in the gastric juice of individuals with H. pylori infection.Eighteen H. pylori-infected dyspeptic male volunteers without endoscopic lesions were enrolled in a study with an open, randomized, two-period crossover design and a 21-day washout period between phases. Plasma and gastric juice concentrations of clarithromycin in subjects with and without omeprazole pretreatment were measured by means of liquid chromatography coupled to tandem mass spectrometry.The maximum concentration of clarithromycin (Cmax) and the area under the time-concentration curve from 0 to 2 h (AUC0-2h) were significantly higher in gastric juice than in plasma. Omeprazole treatment further augmented clarithromycin Cmax and AUC0-2h in gastric juice approximately 2-fold (P0.05).Short-term treatment with omeprazole in H. pylori-positive volunteers increases the amount of clarithromycin transferred to the gastric juice, confirming a synergism between these drugs. Our results suggest the presence of an active transport mechanism for clarithromycin from plasma to the gastric lumen, which is influenced by omeprazole. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|