Low Levels of Vitamin D Promote Memory B Cells in Lupus
| Autor: | Jessica Liu, Jane K. Nguyen, Trine N. Jørgensen, Cun-Jin Zhang, Nicole Campbell, Howard Smith, Emma J. Keller, Xiaoxia Li, Erin A. Yamamoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Vitamin vitamin D3 medicine.medical_specialty lcsh:TX341-641 Systemic Lupus Erythematosus Article vitamin D deficiency Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine immune system diseases Internal medicine medicine Vitamin D and neurology memory B cells Animals Humans Lupus Erythematosus Systemic Vitamin D Risk factor Th17 cells Memory B cell skin and connective tissue diseases B cell Cholecalciferol B-Lymphocytes Nutrition and Dietetics Systemic lupus erythematosus business.industry Vitamin D Deficiency medicine.disease Peripheral Disease Models Animal 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Immunoglobulin G Dietary Supplements Female Act1 business lcsh:Nutrition. Foods and food supply 030215 immunology Food Science |
| Zdroj: | Nutrients Volume 12 Issue 2 Nutrients, Vol 12, Iss 2, p 291 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12020291 |
| Popis: | Background: Vitamin D deficiency is a known risk factor for Systemic Lupus Erythematosus (SLE), yet clinical trials have not demonstrated efficacy and few studies have utilized lupus models to understand the mechanism underlying this relationship. The Act1-/- mouse is a spontaneous model of lupus and Sjö gren&rsquo s syndrome, characterized by increased Th17 cells and peripheral B cell expansion. Vitamin D3 has anti-inflammatory properties, reduces Th17 cells and impairs B cell differentiation/activation. Therefore, we assessed how varying amounts of vitamin D3 affected lupus-like disease in the Act1-/- mouse. Methods: Act1-/- mice were fed either low/restricted (0 IU/kg), normal (2 IU/kg), or high/supplemented (10 IU/kg) vitamin D3 chow for 9 weeks, after which lupus-like features were analyzed. Results: While we found no differences in Th17 cells between vitamin D3 groups, vitamin D3 restriction specifically promoted memory B cell development, accompanied by elevated levels of serum IgM, IgG1, IgG3, and anti-dsDNA IgG. A similar significant negative association between serum vitamin D and memory B cells was confirmed in a cohort of SLE patients. Conclusion: Low levels of vitamin D3 are associated with elevated levels of memory B cells in an animal model of lupus and well-controlled SLE patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|