The Kinetics of Ampicillin Release from Hydroxyapatite for Bones Regeneration

Autor:	Andrea Lopes de Oliveira Ferreira, José Sílvio Veras Albuquerque, Caroliny Gomes de Oliveira, Ricardo Emílio Ferreira Quevedo Nogueira, Giovanilton Ferreira da Silva
Rok vydání:	2009
Předmět:	Bones regeneration Article Subject Low toxicity Kinetic model medicine.drug_class Chemistry General Chemical Engineering Kinetics Antibiotics Chemical engineering Adsorption Ampicillin Drug delivery medicine TP155-156 medicine.drug Biomedical engineering
Zdroj:	International Journal of Chemical Engineering, Vol 2009 (2009)
ISSN:	1687-8078 1687-806X
DOI:	10.1155/2009/273808
Popis:	Semisynthetic beta-lactam antibiotics are among the most used pharmaceuticals. Their use in veterinary and human medicine is in continuous expansion. There is a growing need for developing bioactive implants. Advantages of implantable drug delivery tools can include high release efficiency, precise dose control, low toxicity, and allow to overcome disadvantages connected with conventional methods. In this respect, hydroxyapatite (HA) is an elective material. It enables to produce architectures similar to those of real bones. Here we studied a kinetic model to describe ampicillin release from HA. In the course of adsorption experiment, ampicillin was dissolved, maintained at and shaken at 60 strokes/minute. Samples were withdrawn periodically for analysis and then returned to the mixture. Adsorbed amounts were measured by the difference of the concentration of the antibiotics before and after adsorption using UV adsorption at 225 nm. The aim of this work was to evaluate its application as ampicillin delivery carrier.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf6eeef05e58bf2370e197c8a8cbb00 https://doi.org/10.1155/2009/273808 Zobrazit plný text záznamu Plný text ve formátu PDF