Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis
| Autor: | Francis Foata, Oskar Adolfsson, Gloria Reuteler, Christoph Mueller, Genevieve Perruisseau-Carrier, David Philippe, Karine Vidal, Laurent Favre, Johanna Dayer-Schneider, Stephanie Blum |
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| Rok vydání: | 2011 |
| Předmět: |
Adoptive cell transfer
Microbiological culture T cell T-Lymphocytes Inflammation digestive system Epithelial Damage 03 medical and health sciences Feces Mice 0302 clinical medicine fluids and secretions Oral administration medicine Animals Humans Colitis 030304 developmental biology Diminution 0303 health sciences business.industry Probiotics Body Weight Gastroenterology food and beverages General Medicine medicine.disease Adoptive Transfer 3. Good health Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Immunology bacteria 030211 gastroenterology & hepatology Original Article Bifidobacterium medicine.symptom business Biomarkers |
| Zdroj: | World journal of gastroenterology |
| DOI: | 10.3748/wjg.v17.i4.459 |
| Popis: | AIM: To assess the anti-inflammatory effect of the pro-biotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. |
| Databáze: | OpenAIRE |
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