Studies on new platelet aggregation inhibitors 1. Synthesis of 7-nitro-3,4-dihydroquinoline-2(1H)-one derivatives
| Autor: | Kouji Kamata, Masahiko Uchida, Yukihiko Hotei, Akira Iyobe, Hiroshi Kusama, Hiromu Harada |
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| Rok vydání: | 2001 |
| Předmět: |
Chronotropic
Cardiotonic Agents Magnetic Resonance Spectroscopy Platelet Aggregation Stereochemistry Guinea Pigs Nitro compound In Vitro Techniques Quinolones Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Animals Heart Atria chemistry.chemical_classification Bicyclic molecule Acetylation General Chemistry General Medicine Nitro Compounds Myocardial Contraction chemistry Lactam Nitro Platelet aggregation inhibitor Indicators and Reagents Rabbits Divergent synthesis Platelet Aggregation Inhibitors |
| Zdroj: | Chemicalpharmaceutical bulletin. 49(7) |
| ISSN: | 0009-2363 |
| Popis: | A series of 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H)-ones were prepared and tested for platelet aggregation inhibitory effect, cardiotonic activity and chronotropic activity. These compounds appeared to show selective inhibitory activity against platelet aggregation. Among them, 6-(4-ethoxycarbonylpiperidino)-7-nitro-3,4-dihydroquinoline-2(1H)-one (22f) showed the most potent inhibitory activity and high selectivity. A divergent synthetic route to 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H)-one derivatives has also been investigated. |
| Databáze: | OpenAIRE |
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