The utility of the forced oscillation technique in assessing bronchodilator responsiveness in patients with asthma
| Autor: | Makito Yaegashi, Albert E. Heurich, Michael J. Akerman, Venkata A.K. Yalamanchili, Vaidehi Kaza, Jeremy Weedon |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty medicine.drug_class Pulmonary function testing law.invention Airway resistance Forced Oscillation Technique Impulse oscillometry system (IOS) law Bronchodilator Internal medicine Forced Expiratory Volume Oscillometry medicine Humans Asthma Retrospective Studies COPD Anthropometry business.industry Airway Resistance Forced oscillation Middle Aged medicine.disease Surgery Bronchodilator Agents Respiratory Function Tests Treatment Outcome Ethanolamines Cardiology Female Airway obstruction business Pirbuterol Spirometer medicine.drug |
| Zdroj: | Respiratory Medicine. 101(5):995-1000 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2006.09.001 |
| Popis: | Summary Objective : To address the utility of the forced oscillation technique (FOT) in assessing bronchodilator responsiveness compared with forced expiratory volume in 1s (FEV 1 ). Methods : This is a retrospective analysis of consecutive 126 patients with a clinical history of asthma without any other lung diseases at a pulmonary function testing laboratory. The following measurements were obtained three times each, before and after two doses of pirbuterol 0.2mg inhalation: the respiratory resistance at 5Hz ( R rs5), the mean respiratory resistance between 5 and 20Hz ( R rs5–20), and the mean respiratory conductance (Grs5–20) by FOT and the FEV 1 by spirometer. These measurements were transformed into dimensionless subject-specific effect-size " d -scores" by dividing them by the estimated pooled within-subject standard deviation. Results : Descriptive statistics for each value were the following [mean baseline value (±sd), Δ value (pre- minus post value), and d -score ( P value compared to FEV 1 )]: Grs5–20 (Ls −1 kPa −1 ) [1.79±0.53, Δ =+0.39, d =2.64 ( P R rs5–20 (kPaL −1 s) [0.60±0.16L, Δ =−0.10, d =2.56 ( P =0.001)], R rs5 (kPaL −1 s) [0.78±0.25, Δ =−0.16, d =2.52 ( P 1 (L) [1.90±0.64, Δ =−0.20, d =1.83]. The higher d -score of Grs5–20, R rs5–20 and R rs5 compared to FEV 1 indicates that these are better indicators for bronchodilator response than FEV 1 . The percentages of subjects exhibiting change in the expected direction after bronchodilator were not significantly different between each value: R rs5 (85.7%), R rs5–20 (83.3%), Grs5–20 (83.3%), and FEV 1 (83.3%) [ P >0.05]. Conclusions : Several forced oscillation measures, namely Grs5–20, R rs5–20 and R rs5, are more accurate and sensitive for detecting bronchodilator response than FEV 1 in patients with asthma. |
| Databáze: | OpenAIRE |
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