Altered duodenal bile salt concentration and receptor expression in functional dyspepsia
| Autor: | Patrick Augustijns, Tim Vanuytsel, Ricard Farré, Dorien Beeckmans, Danny Riethorst, Hanne Vanheel, Jan Tack |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
duodenal permeability DISORDERS Receptor expression Salt (chemistry) Pharmacology Bile salts Calcitriol receptor GUT MICROBIOME DISEASE 03 medical and health sciences 0302 clinical medicine Functional gastrointestinal disorder FLUIDS medicine vitamin D receptor chemistry.chemical_classification Intestinal permeability Science & Technology Gastroenterology & Hepatology business.industry digestive oral and skin physiology Gastroenterology Original Articles medicine.disease functional dyspepsia ACIDS VITAMIN-D-RECEPTOR digestive system diseases Pathophysiology STATE 030104 developmental biology Oncology chemistry GASTROINTESTINAL-TRACT 030211 gastroenterology & hepatology business Life Sciences & Biomedicine |
| Zdroj: | United European gastroenterology journal. 6(9) |
| ISSN: | 2050-6406 |
| Popis: | BACKGROUND: Functional dyspepsia is a common functional gastrointestinal disorder in which a variety of pathophysiological mechanisms such as increased intestinal permeability and low-grade inflammation are involved. The factor causing these alterations, however, has not been identified. OBJECTIVE: We aimed to evaluate the luminal bile salt content and receptor expression in patients with functional dyspepsia and healthy volunteers. METHODS: Gastroduodenoscopy was performed to obtain duodenal biopsies from 25 healthy volunteers and 25 patients with functional dyspepsia (Rome III) to measure duodenal bile salt receptor expression with Western blot. Duodenal fluid aspirates were collected at fixed time points during fasted and fed state conditions and bile salt composition analysis was performed by liquid chromatography-mass spectrometry/mass spectrometry. RESULTS: Patients (N = 17) displayed decreased fasted bile salt concentrations compared to healthy volunteers (N = 20) over time (1.8 ± 0.3 mM vs 3.6 ± 0.5 mM; p = 0.03). In addition, an increased expression of duodenal bile salt sensor vitamin D receptor was found in patients (3.7 ± 1.0-fold; p |
| Databáze: | OpenAIRE |
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