Aloe-Emodin Quinone Pretreatment Reduces Acute Liver Injury Induced by Carbon Tetrachloride
| Autor: | Beatrice Arosio, Nicoletta Gagliano, Lorena Maria Pia Fusaro, Paola Galetti, Jacopo Tagliabue, Giorgio Annoni, Luciano Parmeggiani, Diego De Castri, Claudia Moscheni |
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| Přispěvatelé: | Arosio, B, Gagliano, N, Fusaro, L, Parmeggiani, L, Tagliabue, J, Galetti, P, De Castri, D, Mocheni, C, Annoni, G |
| Rok vydání: | 2000 |
| Předmět: |
Male
Emodin Necrosis Health Toxicology and Mutagenesis Anthraquinones Antineoplastic Agents Pharmacology Toxicology digestive system Aloe emodin Rats Sprague-Dawley Lipid peroxidation lipid-peroxidation gene-expression mitochondria chemistry.chemical_compound Blood serum Albumins medicine Animals Drug Interactions Aspartate Aminotransferases RNA Messenger Carbon Tetrachloride Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha digestive oral and skin physiology Albumin Blotting Northern digestive system diseases Rats Disease Models Animal medicine.anatomical_structure Liver chemistry Biochemistry Hepatocyte Toxicity Carbon tetrachloride Chemical and Drug Induced Liver Injury MED/09 - MEDICINA INTERNA medicine.symptom Injections Intraperitoneal medicine.drug |
| Zdroj: | Pharmacology and Toxicology. 87:229-233 |
| ISSN: | 1600-0773 0901-9928 |
| Popis: | Aloe contains several active compounds including aloin, a C-glycoside that can be hydrolyzed in the gut to form aloe-emodin anthrone which, in turn, is auto-oxidized to the quinone aloe-emodin. On the basis of the claimed hepatoprotective activity of some antraquinones, we studied aloe-emodin in a rat model of carbon tetrachloride (CCl 4 ) intoxication, since this xenobiotic induces acute liver damage by lipid peroxidation subsequent to free radical production. Twelve rats were treated with CCl 4 (3 mg/kg) intraperitoneally and six were protected with two intraperitoneally injections of aloe-emodin (50 mg/kg: CCl 4 +aloe-emodin); six other rats were only aloe-emodin injected (aloe-emodin) and six were untreated (control). Histological examination of the livers showed less marked lesions in the CCl 4 +aloe-emodin rats than in those treated with CCl 4 alone, and this was confirmed by the serum levels of L-aspartate-2-oxoglutate-aminotransferase (394±38.6 UI/l in CCl 4 , 280±24.47 UI/l in CCl 4 +aloe-emodin rats; P |
| Databáze: | OpenAIRE |
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