Survival and prognostic factors after initiation of treatment in Waldenstrom's macroglobulinemia
| Autor: | Elina Vervessou, Dimitra Gika, N. Anagnostopoulos, G. Kouvatseas, George Hamilos, Irini Xilouri, T. Economopoulos, A. Zomas, T. Karmiris, K. Matsis, Meletios A. Dimopoulos, K. Bourantas, Konstantinos Zervas, Paraskevi Roussou, Argiris Symeonidis, C. Mitsouli |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Anemia Gastroenterology Risk Assessment Severity of Illness Index Cohort Studies Sex Factors Internal medicine Cause of Death Severity of illness Antineoplastic Combined Chemotherapy Protocols medicine Humans Cyclophosphamide Melphalan Survival analysis Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Analysis of Variance business.industry Proportional hazards model Age Factors Waldenstrom macroglobulinemia Macroglobulinemia Hematology Middle Aged medicine.disease Prognosis Survival Analysis Surgery Lymphoma Treatment Outcome Oncology Doxorubicin Vincristine Multivariate Analysis Prednisone Female Waldenstrom Macroglobulinemia business |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 14(8) |
| ISSN: | 0923-7534 |
| Popis: | Backgroud: Waldenstrom’s macroglobulinemia (WM) is an unusual lymphoplasmacytoid lymphoma characterized by the presence of a serum monoclonal immunoglobulin M. Although several studies have evaluated possible prognostic factors of this disease, few have focused on the survival and prognosis of symptomatic patients after the initiation of treatment. Patients and methods: Our study included 122 previously untreated patients with a median age of 67 years who required systemic treatment. Multiple variables were analyzed for their prognostic value on survival after initiation of treatment using univariate and Cox regression multivariate analysis. Results: The median overall survival was 106 months. Pretreatment factors associated with shorter survival were age ≥65 years, splenomegaly, B-symptoms (weight loss, fever or night sweats), hemoglobin |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|