Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele
| Autor: | Carlos Ruiz-Alegria, Yolanda Bravo, Natalia Valle, Pedro Muñoz, Jesus Castillo, Carmen Cid, Agustín Oterino, Pablo Sánchez-Velasco, Julio Pascual, Francisco Leyva-Cobián |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Migraine Disorders Methenyltetrahydrofolate Cyclohydrolase MTHFD1 Thymidylate synthase Formate-Tetrahydrofolate Ligase Cellular and Molecular Neuroscience Folic Acid Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Methionine synthase Allele Promoter Regions Genetic Molecular Biology Methylenetetrahydrofolate Reductase (NADPH2) Genetics Polymorphism Genetic Methenyltetrahydrofolate cyclohydrolase biology Thymidylate Synthase Middle Aged medicine.disease Migraine with aura Endocrinology Migraine Tandem Repeat Sequences Case-Control Studies Methylenetetrahydrofolate reductase biology.protein Female medicine.symptom |
| Zdroj: | Molecular Brain Research. 139:163-168 |
| ISSN: | 0169-328X |
| DOI: | 10.1016/j.molbrainres.2005.05.015 |
| Popis: | There is growing evidence that folate metabolism is involved in migraine pathophysiology, mainly in migraine with aura. Even though folate metabolism is regulated by a number of enzymes, only two functional polymorphisms have been tested in association studies with migraine. Here, we have explored the possible role in migraine of other folate-metabolizing enzymes which are in close interdependency with 5′,10′-methylenetetrahydrofolate reductase analyzing functional polymorphisms of these enzymes in a case-control study. Individually, thymidylate synthase (TS), methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthase (MTHFD1), or methionine synthase (MS) polymorphisms did not modify the general risk for suffering migraine. Nevertheless, we observed a strong interaction between TS and MTHFR mutated genotypes, which increased over 8-fold the risk for experiencing aura among migraineurs; MTHFD1 and MTHFR mutated genotypes also increased together the risk for migraine in general (OR = 3.08; 95% CI = 1.3–7.4). We conclude that the pathogenetic role of the MTHFR T677 allele in migraine is modulated by functional polymorphisms of TS and MTHFD1. |
| Databáze: | OpenAIRE |
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