| Autor: |
Subramaniam Malarkannan, Tiffany Horng, Nilabh Shastri, Nathalie Brouwenstijn, Greg J. Christianson, Patty P. Shih, Derry C. Roopenian, Heiko Klinge, Federico Gonzalez, Peter A. Eden |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Immunity. 13(3):333-344 |
| ISSN: |
1074-7613 |
| DOI: |
10.1016/s1074-7613(00)00033-9 |
| Popis: |
Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/Kb and our previously identified H60/Kb complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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