Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold
| Autor: | Jianwu Dai, Na Yin, Shixiang Cheng, Huilin Yang, Lingjun Wang, Keran Song, Junjie Niu, Shuxun Hou, Guang Han, Yannan Zhao, Qiaoling Chen, Jiaguang Tang, Fengwu Tang, Ziqiang Wang, Yumei Chen, Qin Shi, Zhifeng Xiao, Xianfeng Jiang, Changyu Zhao, Zhiwei Zhang, Sai Zhang, Bing Chen, Zhang Jiaojiao, Liang Chen |
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| Rok vydání: | 2021 |
| Předmět: |
Tissue Scaffolds
business.industry Mesenchymal stem cell Mesenchymal Stem Cells Mesenchymal Stem Cell Transplantation medicine.disease Umbilical cord General Biochemistry Genetics and Molecular Biology Nerve Regeneration Transplantation medicine.anatomical_structure Injury Site Spinal Cord Anesthesia medicine Animals Humans Bone marrow Stem cell General Agricultural and Biological Sciences business Adverse effect Spinal cord injury Spinal Cord Injuries General Environmental Science |
| Zdroj: | Science China Life Sciences. 65:909-926 |
| ISSN: | 1869-1889 1674-7305 |
| DOI: | 10.1007/s11427-021-1985-5 |
| Popis: | Spinal cord injury (SCI) often results in an inhibitory environment at the injury site. In our previous studies, transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI. Based on these preclinical studies, collagen scaffolds loaded with the patients' own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients. Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years. No serious adverse events related to functional scaffold transplantation were observed. Among the patients with acute SCI, five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder. Additionally, four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction. Among patients with chronic SCI, 16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site. Nearly half of the patients with chronic cervical SCI developed enhanced finger activity. These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. |
| Databáze: | OpenAIRE |
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