Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity
| Autor: | Fidel Gallinas-Victoriano, María Jesús Chueca-Guindulain, Paula Moreno-González, María Urretavizcaya-Martinez, Teodoro Durá-Travé, Diego Mauricio Peñafiel-Freire |
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| Rok vydání: | 2020 |
| Předmět: |
Cardiometabolic risks factors
medicine.medical_specialty Waist severe obesity Adolescents Body fat percentage Article vitamin D deficiency Insulin resistance Internal medicine medicine Vitamin D and neurology Mass index adolescents Vitamin D business.industry cardiometabolic risks factors lcsh:RJ1-570 lcsh:Pediatrics medicine.disease Obesity Endocrinology Pediatrics Perinatology and Child Health Severe obesity business Body mass index |
| Zdroj: | Children Volume 7 Issue 2 Children, Vol 7, Iss 2, p 10 (2020) |
| ISSN: | 2227-9067 |
| Popis: | Background/Objectives. Obesity is associated with cardiometabolic risk factors and with Vitamin D deficiency. The aim of this study was to examine the relationship between 25(OH)D concentrations and cardiometabolic risk factors in adolescents with severe obesity. Subjects/Methods. A cross-sectional clinical assessment (body mass index, fat mass index, fat-free mass index, waist-to-height ratio, and blood pressure) and metabolic study (triglycerides, total cholesterol, HDL-C, LDL-C, glucose, insulin, HOMA-IR, leptin, calcium, phosphorous, calcidiol, and PTH) were carried out in 236 adolescents diagnosed with severe obesity (BMI z-score > 3.0, 99th percentile), aged 10.2&ndash 15.8 years. The criteria of the US Endocrine Society were used for the definition of Vitamin D status. Results. Subjects with Vitamin D deficiency had significantly elevated values (p < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status. There was a significant negative correlation (p < 0.05) of serum 25(OH)D levels with body fat percentage, FMI, systolic BP, total cholesterol, triglyceride, LDL-C, glucose, insulin, HOMA-IR, leptin, and PTH. Conclusions. Low Vitamin D levels in adolescents with severe obesity were significantly associated with some cardiometabolic risk factors, including body mass index, waist circumference, fat mass index, high blood pressure, impaired lipid profile, and insulin resistance. |
| Databáze: | OpenAIRE |
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