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POTOCKA, Zofia, BORYCKA, Aleksandra, JĘDRZEJEWSKA, Barbara, KOTULSKA, Maria, LASKUS, Paulina, LICHMAN,Martyna, LUBCZYŃSKA, Zuzanna, PRZERADZKI, Jakub & RZĄD, Katarzyna. Potential clinical usage of ashwagandha root extract: A review.Journal of Education, Health and Sport. 2023;29(1):35-44. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.29.01.004 https://apcz.umk.pl/JEHS/article/view/43613 https://zenodo.org/record/7929922 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 18.04.2023. Revised: 20.04.2023. Accepted: 15.05.2023. Published: 15.05.2023. POTENTIAL CLINICAL USAGE OF ASHWAGANDHA ROOT EXTRACT: A REVIEW Zofia Potocka Państwowy Instytut Medyczny MSWiA w Warszawie, ul. Wołoska 137, 02-507 Warsaw, Poland https://orcid.org/0009-0008-7738-2795 zosia@potocka.eu Aleksandra Borycka Państwowy Instytut Medyczny MSWiA w Warszawie, ul. Wołoska 137, 02-507 Warsaw, Poland https://orcid.org/0009-0002-5589-1827 aborycka1997@gmail.com Barbara Jędrzejewska Powiatowe Centrum Zdrowia w Otwocku, ul. Stefana Batorego 44, 05-400 Otwock, Poland https://orcid.org/0009-0002-2153-4311 barbarajedrzejewska97@gmail.com Maria Kotulska Państwowy Instytut Medyczny MSWiA w Warszawie, ul. Wołoska 137, 02-507 Warsaw, Poland https://orcid.org/0009-0003-9111-6745 marysia.kotulska1997@gmail.com Paulina Laskus Międzyleski Szpital Specjalistyczny w Warszawie, ul. Bursztynowa 2, 04-749 Warsaw, Poland https://orcid.org/0009-0006-6882-8797 pa11ulina.pl@gmail.com Martyna Lichman Szpital Chirurgii Urazowej św. Anny, ul. Barska 16/20, 02-315 Warsaw, Poland https://orcid.org/0009-0007-5473-4973 martyna.lichman@gmail.com Zuzanna Lubczyńska Szpital Grochowski im. dr med. Rafała Masztaka, ul. Grenadierów 51/59, 04-073 Warsaw, Poland https://orcid.org/0000-0002-4860-2508 zuzanna.smiech@gmail.com Jakub Przeradzki Międzyleski Szpital Specjalistyczny w Warszawie, ul. Bursztynowa 2, 04-749 Warsaw, Poland https://orcid.org/0009-0001-2941-6670 kprzerad@o2.pl Katarzyna Rząd Międzyleski Szpital Specjalistyczny w Warszawie, ul. Bursztynowa 2, 04-749 Warsaw, Poland https://orcid.org/0009-0000-3611-7479 kasia.rzad@gmail.com ABSTRACT INTRODUCTION AND OBJECTIVE Ashwagandha, an herb commonly used in traditional Indian medicine, has been gathering attention as a potential drug in various specialties such as psychiatry, neurology, or endocrinology and even as a possible cancer treatment. In this review we aim to summarize reports form recent years on potential clinical usage of Ashwagandha. REVIEW METHODS The literature review was conducted using PubMed and Google Scholar online databases. THE STATE OF KNOWLEDGE Several studies evaluating potential pharmacological uses of Ashwagandha root extract has been published. There are clinical trials conducted in India using the plant in treatment of insomnia that resulted in improved sleep quality. Ashwagandha root extract has been successfully administered in stress-related disorders. There arereports of improvement in cognitive functions in patients with mild cognitive impairment and better symptom control in obsessive-compulsive disorder after Ashwagandha supplementation. Ashwagandha has been studied in endocrine diseases, showing potential in alleviating climacteric symptoms during perimenopause and in subclinical hypothyroidism. The study aimed to assess effect of Ashwagandha on vitality and hormonal changes in elderly men showed mixed results, with improvement in some hormonal levels and not statistically significant improvement in quality of life compared to placebo group. It has also been noted that Ashwagandha root extract has positive effect on cardiovascular system, as well as enhancing muscle strength and recovery in otherwise healthy adults. SUMMARY Ashwagandha root extract seems to possess beneficial properties that allow for its use in several branches of medicine. However as current findings are reported from small sample studies, further research on a larger scale is needed. KEYWORDS: Ashwagandha; Withania somnifera; Review; Clinical trial; herbal |
