A retrospective investigation of minor risk factors as prognostic predictors and treatment indications in oral squamous cell carcinoma
| Autor: | Takeshi Uehara, Hiroki Otagiri, Akinari Sakurai, Hironori Sakai, Kiriko Kubo, Kazunori Anzai, Shin-ichi Yamada, Yusuke Hakoyama, Yukiko Akahane, Koichi Goto, Naoki Matsumura, Junichi Yajima, Hiroshi Kurita, Masafumi Morioka, Eiji Kondo, Masao Hashidume |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate analysis Minor risk factor Perineural invasion 03 medical and health sciences 0302 clinical medicine Internal medicine Overall survival Medicine Clinical significance Basal cell General Dentistry business.industry Hazard ratio 030206 dentistry Prognosis Pattern of invasion Confidence interval lcsh:RK1-715 stomatognathic diseases Oral squamous cell carcinoma Depth of invasion lcsh:Dentistry 030220 oncology & carcinogenesis Original Article business |
| Zdroj: | Journal of Dental Sciences Journal of Dental Sciences, Vol 16, Iss 1, Pp 445-452 (2021) |
| ISSN: | 2213-8862 1991-7902 |
| Popis: | Background/purpose: The clinical significance of minor risk factors remins uncertain in oral squamous cell carcinoma (OSCC) patients. The purpose of this study was to investigate the clinical impact of minor risk factors in OSCC patients. Materials and methods: The cases of OSCC patients that underwent surgery were retrospectively analyzed. Patients with major risk factors for recurrence, such as positive surgical margins or extracapsular spread, were excluded. The impact of possible minor risk factors on treatment outcomes was analyzed. One hundred and seventy-five patients with primary OSCC that underwent surgery were included in this study. Results: The 5-year overall survival (OS), cancer-specific survival (CSS), and relapse-free survival (RFS) rates were 81.2%, 91.0%, and 72.4%, respectively. In multivariate analyses, RFS exhibited a significant association with the pattern of invasion (grade 4 vs. grades 1–3: hazard ratio: 3.096, 95% confidence interval: 1.367–6.884, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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