CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials
| Autor: | Thomas F. Lüscher, Thomas Münzel, Thomas Meinertz, Matthias Hermann, Kurt Quitzau, Michael M. Hoffmann, Dieter Fischer, Theo Gasser |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Heterozygote Ischemia Lipopolysaccharide Receptors Single-nucleotide polymorphism Coronary Artery Disease Polymerase Chain Reaction Polymorphism Single Nucleotide Risk Assessment Proinflammatory cytokine Coronary artery disease Gene Frequency Risk Factors Internal medicine Intravascular ultrasound medicine SNP Humans Genetic Predisposition to Disease Ultrasonography Interventional Aged Randomized Controlled Trials as Topic Retrospective Studies Chi-Square Distribution medicine.diagnostic_test biology business.industry C-reactive protein Middle Aged medicine.disease Plaque Atherosclerotic C-Reactive Protein Phenotype Concomitant biology.protein Cardiology Female Inflammation Mediators Cardiology and Cardiovascular Medicine business |
| Zdroj: | Atherosclerosis. 220(1) |
| ISSN: | 1879-1484 |
| Popis: | Background Several proinflammatory single-nucleotide polymorphisms (SNPs) have been linked to the progression of atherosclerosis and coronary artery disease (CAD). Plaque size and its destabilization by inflammatory processes are major determinants of ischemia and acute coronary syndromes. Intravascular ultrasound (IVUS) allows for quantification of plaque size in vivo. We therefore investigated the relation of plaque size with mutations of proinflammatory genes in patients with CAD. Methods In 196 patients with stable CAD enrolled in the ENCORE trials coronary plaque and vessel volume was assessed by IVUS. 173 patients were successfully genotyped for polymorphisms of proinflammatory genes CD14 C(−260)T and CRP C(+1444)T using the single-nucleotide polymorphism polymerase chain reaction (SNP PCR) approach. Results Baseline characteristics were comparable for all genotype groups. Higher ratios of plaque volume/vessel volume were observed in patients with the CRP 1444TT ( n = 11) and CD14 260TT ( n = 33) genotypes ( p = 0.016 and p = 0.026, respectively). Conclusion In patients with stable coronary artery disease the CRP 1444TT and CD14 260TT variants are associated with larger coronary plaque volume independently of concomitant cardiovascular risk factors. |
| Databáze: | OpenAIRE |
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